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FAQ: What is the Relationship Between CBD & Autoimmune disorders?

Autoimmune Diseases such as: Lupus, Psoriasis, Type 1 Diabetes, Rheumatoid Arthritis, Inflammatory Bowel Disease, etc. have shown to be linked to stress. For example, in this study citing a higher incidence of autoimmune diseases among people who were previously diagnosed with stress-related disorders. Another paper publishes:

Physical and psychological stress has been implicated in the development of autoimmune disease, since numerous animal and human studies demonstrated the effect of sundry stressors on immune function. Moreover, many retrospective studies found that a high proportion (up to 80%) of patients reported uncommon emotional stress before disease onset.

It is presumed that the stress-triggered neuroendocrine hormones lead to immune dysregulation, which ultimately results in autoimmune disease, by altering or amplifying cytokine [inflammatory response] production. The treatment of autoimmune disease should thus include stress management and behavioral intervention to prevent stress-related immune imbalance. “

Because of CBD’s ability to combat stress levels (see previous blog post), it provides as a preventative measure and potential therapy for Autoimmune Disorders as a stress management tool.

**These statements have not been evaluated by the food and drug administration (FDA). These products are not intended to diagnose, treat, cure or prevent any disease. The information is not medical advice, and should not be treated as such. 

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FAQ: How can CBD help my Stress Levels?

Modern-day science continues to show the link between Stress & Disease. Stress can be defined as any experience that causes tension, whether that be physical, psychological, or emotional- and especially if it sets off the “fight or flight” response – during which the adrenal gland releases adrenaline, leading to rapid pulse and breathing, and increased blood pressure).

“Chronic stress result [in] failures of homeostasis, [and] thus lead to various diseases such as atherosclerosis, non-alcoholic fatty liver disease (NAFLD) and depression. However, while 75%–90% of human diseases is related to the activation of stress system, the common pathways between stress exposure and pathophysiological processes underlying disease is still debatable.

Chronic inflammation is an essential component of chronic diseases. Additionally, accumulating evidence suggested that excessive inflammation plays critical roles in the pathophysiology of the stress-related diseases, yet the basis for this connection is not fully understood.” this paper publishes.

In previous blog posts, we have spoken widely about CBD’s potential in regulating inflammation and returning the body to homeostasis. We have even shown how CBD acts in a similar way as antidepressants as it works on the serotonin (5HT)1a receptor. Serotonin deficiency is associated with depression and other psychiatric disorders, and it is likely that the effects CBD has on mood and anxiety are related to this interaction.

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FAQ: Can CBD help with Skin Cancer?

The potential role of cannabinoids (CBD, CBG, etc) as antitumoral drugs is being explored in relation to the inflammatory component of skin cancer.

In vivo and in vitro studies that employed either phyto-, endo-, or synthetic cannabinoids show promise in topical treatment of Skin Cancer.

Cannabinoids are regarded with growing interest as eligible drugs in the treatment of skin inflammatory conditions with potential anticancer effects.

Topical CBD was also found effective in alleviating the symptoms of the following conditions: oxidative stress on dermal cells, skin conditions characterized by inflammation and keratin disorders, such as eczema or atopic dermatitis, wound healing, pain & muscle relief, itch (pruritis), Acne/Seborrhea, modulation of hair growth, skin & hair pigmentation, oral care, and other skin disorders such as antibiotic-resistant skin infections, cutaneous malignancies such as Melanoma, and Psoriatic Plaques.

Many studies currently report these effects, and the readiness in monitoring of effects and the facility of topical application may contribute to the growing support of the use of these substances. Not medical advice.

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FAQ: How do I know how much CBD to take?

“I DON’T REALLY FEEL ANYTHING DIFFERENT.” This is heard so many times among CBD users who are concerned about their dose being low at first. More than likely, too low! And then, consequently, they don’t follow up with what their “sweet spot dose” of CBD truly is. Please read to discover the true dose your body is prepared to receive:

True Natural Oils offers different CBD oils with various strengths. Hence, one drop of full-spectrum CBD oil with 750 mg of CBD concentration is not the same as one drop of full-spectrum CBD oil with 3000mg of CBD. When choosing the best dosage for you, there are some things to be considered.

For example, the CBD concentration in each CBD oil bottle, the user’s body weight and the condition that is to be treated. Even after determining these factors, there is still no ‘one-size-fits-all’ type of dosage. One option is to consume 1-6mg of CBD for every 10 pounds of body weight or to start. You may also consider a trial period where you would determine the most suitable dosage for you.

In comparison, the only FDA approved CBD – Epidiolex – is dosed as follows. Median dose is 12.5 mg/kg given twice daily. Maximum dose is 25 mg/kg given daily. For the median dose, if you weigh 150 pounds then 852 mg of CBD given twice daily would be FDA recommended. Now that is not a feasible dosage for general relief of pain or anxiety. It would require many ml’s of the oils to achieve this dosage.

What I would like to point out is that the FDA deems that dosage as a safe treatment dosage. Always consult with a doctor or contact the provider to get more information and some tips. You could experience tiredness, diarrhea or lightheadedness if your dosage is off. In some cases, there might be a change in weight as well. *This is not medical advice.*

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FAQ: Can CBD affect my Heart Health & Blood Pressure?

The Month of February is all about Hearts. It is designated as Heart Health Month in the US, a time when all people can focus on their cardiovascular health.

Cardiovascular diseases (CVDs) are the leading cause of mortality worldwide. They have a set of characteristic molecular components, such as a proinflammatory profile present in heart failure (HF), diabetic cardiomyopathy, and autoimmune myocarditis.

All of these molecular components associated with diverse CVDs can be modulated with Cannabinoid administration. Of particular interest of the Cannabinoids present in Cannabis, which is also produced within our bodies, has been CBD.

CBD is a potent anti-inflammatory and reduces the production of reactive oxygen and nitrogen species, thus resulting in reduced tissue injury. Such effects can be taken advantage of in varied diseases, such as cardiovascular and neurodegenerative diseases, cancer, pain, obesity, and metabolic syndrome.

Hypertension, or high blood pressure, is often called the ‘silent killer’ because most people who have it don’t have any symptoms. This can be a scary notion if we let it be, but we can also choose to take care of our bodies by making healthy choices to maintain our overall wellness.

A recent 2017 study on cardiac parameters in healthy males showed that subjects who had taken CBD, as opposed to a placebo, experienced lower blood pressure when exposed to stress.

In a 2009 study on rats, they were subjected to stressful situations, which in turn increased their heart rate and blood pressure. When the rats were then given a dose of CBD, their blood pressure and heart rate lowered.

It is proven high blood pressure can lead to stroke, heart attack, vision loss and kidney disease. However, we have now seen how CBD can be of great value as a cardioprotective agent due to its potent antioxidant and anti-inflammatory properties. 

As advocates in the CBD industry, our team is pleased to see many clinical studies employing the use of CBD as potential treatments of such destructive diseases. We also know encourage our community to remember that CBD is not a cure-all, though it can help. A balanced diet, mindset, and lifestyle are just as important in maintaining a healthy body and a health heart.

Thank you for letting us share this information with you. As always, this is not Medical Advice. Consult your trusted health professional, especially if you are on any prescribed medication.

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FAQ: Could CBD help my Anxiety?

It is suggested that CBD could be helpful in the treatment of anxiety and stress by many clinical trials and organizations such as this report by the WHO. Note the many benefits attributed to CBD oil—everything from curing insomnia and improving glaucoma, to reducing inflammation and lessening ANXIETY.

CBD has a broad pharmacological profile, including interactions with several receptors known to regulate fear and anxiety-related behaviors, specifically the CB1 receptor, the serotonin 5-HT1A receptor, and the transient receptor potential (TRP) vanilloid type 1 (TRPV1)receptor.

Thus, maintaining the balance between CB1 receptors and TRPV1 channel activation is crucial for regulating anxiety. 

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FAQ: How can CBD aid my Weight Loss?

CBD has shown major promise in being able to modulate metabolism, as well as fat cells in the body.⁣

⁣One study reports, “These data suggest possible roles for CBD in browning of white adipocytes, augmentation of lipolysis, thermogenesis, and reduction of lipogenesis. Thus, CBD may be explored as a potentially promising therapeutic agent for the prevention of obesity.”⁣

This means that CBD can play a role in the formation and regulation of fat cells as well as the storage and breakdown of fat.

This also means that if weight is needed on the body, CBD can also help in that sense as CBD helps to rebalance homeostasis within the body.

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FAQ: What is Whole Plant Extract, Broad Spectrum & CBD Isolate?

The whole plant refers to the entire bud with some leaves and possibly some stems. The buds are what is used to obtain extracts that are being compared to the isolated, pure CBD or THC cannabinoids.

Fullspectrum CBD is full of all the terpenes, cannabinoids, flavonoids, and fatty acids found in hemp, all of which have therapeutic value of their own and help create what’s know as the entourage effect. Broadspectrum CBD is a little bit of both. Broadspectrum CBD is fullspectrum CBD without any THC.

Full spectrum CBD quite simply means the product contains many cannabinoids beyond CBD, along with other elements of the cannabis or hemp plant, including naturally-occurring terpenes, essential vitamins, fatty acids, protein, and more. 

It’s worth emphasizing that CBD itself is entirely non-psychoactive. While full spectrum oil contains small amounts of THC, it does not contain enough THC to produce any psychoactive effects.

The alternative to full spectrum is CBD isolate which contains only CBD – the CBD molecule is chemically isolated from everything else in the plant. CBD isolate is cannabidiol isolated and then refined to strip out any additional cannabinoids, terpenes, and plant components found in the hemp plant. The final product is a fine white powder that contains around 99% cannabidiol.

 CBD isolates have no identifiable amount of THC, the well-known chemical found in cannabis that creates that euphoric high, and they’re stripped of the other beneficial and nutritional compounds like terpenes, flavonoids, vitamins, and protein mentioned above.

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FAQ: How Far Back in History does Using Cannabis Medicinally Go?

It is hard to credit any certain civilization for the exact first use of Cannabis, but it is worth noting that in the first culture to develop a practical form of writing, Cannabis is referenced: The Sumerians (southern Mesopotamia or Iraq) in around 3000 BC.⁣

⁣The earliest Medicinal evidence of the plant is dated to 2800 BCE from the Chinese medical compilation, Pen Ts’ao. Chinese emperor Shen-Nung, referred to as the father of Chinese medicine, prescribed chu-ma (the female THC-producing Cannabis plant, as opposed to the male ma). He even went so far as to deem it one of the “Superior Elixirs of Immortality” (Bennett, 2010).⁣

Chinese Surgeon Hua T’o, who according to the Records of Three Kingdoms (c. AD 270) and the Book of the Later Han (c. AD 430), performed surgery almost 2000 years ago under general anesthesia using a formula he had developed by mixing wine with a mixture of herbal extracts that he called mafeisan, with ma referring to cannabis, fei referring to boiling, and san referring to breaking up or scattering . This word is likely where the modern-day term “morphine” originates.

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FAQ: Is it Safe to Drink Alcohol while Taking CBD?

Alcohol has been shown to cause damage to the frontal and temporal lobes of the brain, in particular by inducing neuroinflammatory mediators and/or oxidative stress. These brain regions are known to be associated with problem solving, attention, information processing, learning, and memory.

Since CBD has neuroprotective effects that prevent oxidative damage, it has been considered for the treatment of cognitive impairments caused by alcohol. These effects of CBD have been hypothesized to be mediated by the 5HT1A (serotonin), or CB2 receptors. 

These exciting results have been reported to support the potential therapeutic benefits of CBD for Alcohol Use Disorder, particularly in the areas of neurodegeneration, hepatotoxicity (chemical-driven liver damage), and  cognition.  Additionally, CBD can have a therapeutic effect in alcoholic liver diseases characterized by inflammation, oxidative stress, and steatosis.

There are several proposed mechanisms through which cannabinoids (and CBD in particular) may confer beneficial effects in the context of Alcohol Use Disorder (AUD). First, CBD may directly impact specific brain mechanisms underlying AUD to influence alcohol consumption and the clinical features of AUD.

Second, CBD may influence AUD symptoms through its actions across the digestive, immune, and central nervous systems, collectively known as the microbiota-gut-brain axis (MGBA). These MGBA disruptions have been associated with AUD symptoms such as craving and impaired cognitive control.

Furthermore, Preclinical data suggest that cannabinoids may confer beneficial effects on the gastrointestinal and immune system. These findings include reducing intestinal permeability, regulating gut bacteria, and reducing inflammation. Thus, cannabinoids may exert AUD harm-reduction effects, at least in part, through their beneficial actions across the MGBA.

Not to mention the effects alcohol has on dehydration. Electrolytes are what our bodies need to absorb water and remain hydrated. When people drink alcohol or caffeine, or exercise, not only do they become more dehydrated, but any water consumed after is not as effective due to a low balance of electrolytes.  Insufficient electrolyte replenishment is a leading cause of why over 75 percent of people are chronically dehydrated.

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