CBD (cannabidiol), the main active ingredient in our products has gained popularity for its potential therapeutic benefits. Our CBD products have been to seen to help with several issues that can be more prevalent during the fall season:
Seasonal Affective Disorder (SAD): SAD is a type of depression that typically occurs in the fall and winter months when there is less natural sunlight. Some people use CBD to help manage the symptoms of SAD, such as low mood and energy levels.
Anxiety and Stress: The fall season can bring about increased stress and anxiety for some people, particularly as holidays approach. CBD is often used as a natural remedy to promote relaxation and reduce anxiety.
Pain and Inflammation: Fall can be associated with more outdoor activities, and some individuals may experience joint pain or inflammation due to changing weather conditions. CBD may have pain-relieving and anti-inflammatory properties.
Sleep Issues: The transition to cooler and darker days in the fall can disrupt sleep patterns. CBD has been used by some individuals to help improve sleep quality and address insomnia.
Immune Support: As the flu season approaches, some people turn to CBD for its potential anti-inflammatory and immune-supporting properties.
CBG, or cannabigerol, is a lesser-known cannabinoid that is found in smaller amounts in the cannabis plant. It is considered a “stem cell” or “mother” cannabinoid because it is a precursor to other cannabinoids such as THC and CBD. CBG has been studied for its potential anti-inflammatory, antibacterial, and neuroprotective effects. CBG has also been studied for its potential use in treating glaucoma, inflammatory bowel disease, and other medical conditions:
Glaucoma: CBG has been shown to have potential neuroprotective effects and may be useful in treating glaucoma, a condition that damages the optic nerve and can lead to vision loss. Merrick J, et al. (2016). Identification of psychoactive degradants of cannabigerol in artificial gastric and physiological fluid. DOI: 10.1007/s00216-015-8688-4
Inflammatory bowel disease (IBD): CBG has been shown to have potential anti-inflammatory effects and may be useful in treating IBD, a group of inflammatory conditions that affect the digestive tract. Borrelli F, et al. (2013). Beneficial effect of the non-psychotropic plant cannabinoid cannabigerol on experimental inflammatory bowel disease. DOI: 10.1038/srep04216
Cancer: CBG has been shown to have potential anti-cancer effects in some preclinical studies, and may be useful in treating certain types of cancer.
Huntington’s disease: CBG has been shown to have potential neuroprotective effects and may be useful in treating Huntington’s disease, a rare genetic disorder that causes progressive degeneration of brain cells. Valdeolivas S, et al. (2015). Neuroprotective properties of cannabigerol in Huntington’s disease: Studies in R6/2 mice and 3-nitropropionate-lesioned mice. DOI: 10.1016/j.ejphar.2015.07.011
Bladder dysfunction: CBG has been shown to have potential therapeutic effects on bladder dysfunction, including overactive bladder and urinary incontinence.
Antibiotic-resistant infections: CBG has been shown to have potential antibacterial effects and may be useful in treating antibiotic-resistant infections caused by bacteria such as MRSA. Appendino G, et al. (2008). Antibacterial cannabinoids from Cannabis sativa: A structure-activity study. DOI: 10.1021/np8002673
Psoriasis: CBG has been shown to have potential anti-inflammatory effects and may be useful in treating psoriasis, a chronic inflammatory skin condition. Wilkinson JD, et al. (2007). Cannabinoids inhibit human keratinocyte proliferation through a non-CB1/CB2 mechanism and have a potential therapeutic value in the treatment of psoriasis. DOI: 10.1111/j.1476-5381.2007.00379.
Pain: CBG has been shown to have potential analgesic (pain-relieving) effects and may be useful in treating various types of pain, including neuropathic pain. Russo EB. (2008). Cannabinoids in the management of difficult to treat pain. DOI: 10.1089/can.2008.0012
Anxiety and depression: CBG has been shown to have potential anxiolytic (anti-anxiety) and antidepressant effects in some preclinical studies. Galaj E, et al. (2020). The role of cannabigerol in reducing anxiety and depression in preclinical models. DOI: 10.3390/ijms21072350
Multiple sclerosis (MS): CBG has been shown to have potential anti-inflammatory effects and may be useful in treating MS, a chronic inflammatory disease that affects the central nervous system. ElSohly MA, et al. (2014). Stability indicating HPLC-UV determination of cannabidiol (CBD) and delta9-tetrahydrocannabinol (THC) in bulk drug and pharmaceutical dosage form. DOI: 10.1016/j.jpba.2013.12.014
Neurodegenerative disorders: CBG has been shown to have potential neuroprotective effects and may be useful in treating neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS). Valdeolivas S, et al. (2012). Cannabigerol attenuates the progression of abeta in vitro and in vivo. DOI: 10.3233/JAD-2012-120675
Acne: CBG has been shown to have potential anti-inflammatory effects and may be useful in treating acne, a common skin condition caused by inflammation. Oláh A, et al. (2016). Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes. DOI: 10.1111/exd.13042
Bone growth: CBG has been shown to have potential osteogenic effects, meaning it may promote bone growth and could be useful in treating conditions such as osteoporosis. Kogan NM, et al. (2015). Cannabidiol, a major non-psychotropic cannabis constituent enhances fracture healing and stimulates lysyl hydroxylase activity in osteoblasts. DOI: 10.1016/j.bone.2015.07.022
Insomnia: CBG has been shown to have potential sedative effects and may be useful in treating insomnia, a sleep disorder that makes it difficult to fall asleep or stay asleep.
Appetite stimulation: CBG has been shown to have potential appetite-stimulating effects and may be useful in treating conditions that cause decreased appetite or weight loss. Farrimond JA, et al. (2012). Cannabinol and cannabidiol exert opposing effects on rat feeding patterns. DOI: 10.1007/s00213-012-2697-x
Cardiovascular disease: CBG has been shown to have potential cardioprotective effects and may be useful in treating cardiovascular diseases such as hypertension and atherosclerosis.
Diabetes: CBG has been shown to have potential antidiabetic effects and may be useful in treating diabetes, a metabolic disorder characterized by high blood sugar levels.
Cardiovascular disease: Bátkai S, et al. (2005). Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension. DOI: 10.1161/01.HYP.0000154767.10345.9c
Parkinson’s disease: In a preclinical study published in the journal Movement Disorders in 2013, researchers found that CBG had potential symptom-relieving and neuroprotective effects in animal models of Parkinson’s disease. Specifically, CBG was found to have antioxidant and anti-inflammatory properties, which may help to protect neurons in the brain from damage and degeneration. García C, et al. (2011). Symptom-relieving and neuroprotective effects of the phytocannabinoid Δ9-THCV in animal models of Parkinson’s disease. DOI: 10.1002/mds.25928
Alcohol addiction: In a preclinical study published in the journal Alcohol and Alcoholism in 2018, researchers found that CBG reduced alcohol intake in rodents. The study also showed that CBG reduced the expression of a protein called GPR55 in the placenta, which is associated with the negative effects of prenatal alcohol exposure. However, more research is needed to determine the potential therapeutic effects of CBG on alcohol addiction in humans. Viudez-Martínez A, et al. (2018). Cannabigerol reduces alcohol intake and placental GPR55 receptors. DOI: 10.1111/acer.13810
Antibacterial activity:Appendino G, et al. (2008). Antibacterial cannabinoids from Cannabis sativa: A structure-activity study. DOI: 10.1021/np8002673
In this CBD basics training video, Rylee and Robin discuss why CBD can be beneficial, and what an “Endocannabinoid Deficiency” is.
They touch on some benefits of CBD, including anti-anxiety, immune system regulation, pain relief, sleep, and inflammation reduction.
They also discuss what to expect when starting CBD. With different Cannabinoids in all their products, Rylee goes into the difference between THC/CBD/CBG/CBN, and why each one can be beneficial.
Robin then shares information on CBD dosage for pets while referencing different studies, and explaining the benefits seen in the each study.
Rylee then dives into the carrier oil for the True Natural Oils & Natural Pet Oil Products: MCT oil. Rylee explains why Medium Chain triglycerides are beneficial for the bioavailability of CBD & for managing energy.
Safety & Dosing is then spoken about by both Robin and Rylee in terms of the best way to take CBD, pharmaceutical drug interactions, how CBD is metabolized in the body, toxicity, and other safety concerns.
At the end, Clint speaks on testing and the quality of our products. Watch our Part 2 for Question & Answers from our team-members!
The recommended dosage of CBD can vary depending on a variety of factors, including body weight, individual tolerance, the condition being treated, and the form of CBD being used (such as oil, capsules, or topicals). It’s always best to consult with a healthcare professional before starting to use CBD, as they can provide personalized recommendations based on your specific needs.
That being said, some general guidelines for dosing CBD have been suggested by experts. A common starting dose is around 5-10mg of CBD, taken once or twice daily. From there, the dosage can be gradually increased over time as needed, up to a maximum of around 1500mg per day. It’s important to start with a low dose and gradually increase it to assess how your body responds to CBD and to minimize the risk of any potential side effects.
CBD (cannabidiol) is generally considered safe, with few reported side effects. According to the World Health Organization (WHO), CBD is well-tolerated by most people and is not associated with abuse potential or dependence. However, as with any supplement or medication, CBD can interact with other medications, so it’s important to talk to a healthcare provider before using CBD if you are taking any prescription medications or have any underlying medical conditions.
Some potential side effects of CBD may include drowsiness, dry mouth, lightheadedness, and changes in appetite or weight. These side effects are generally mild and temporary, and may be less likely to occur at lower doses.
It’s important to note that the safety of CBD products can vary depending on factors such as the quality and purity of the product, as well as how it is manufactured and used. It’s always best to purchase CBD products from reputable sources, and to follow the recommended dosages and usage guidelines.
The time it takes for CBD to take effect can vary depending on a variety of factors, including the form of CBD being used (such as oil, capsules, or topicals), the dose, and the individual’s metabolism and body chemistry.
When using CBD oil or capsules, it can take anywhere from 30 minutes to an hour or more for the effects to be felt. This is because the CBD must first be absorbed into the bloodstream through the digestive system. However, if the CBD is taken sublingually (under the tongue), the effects may be felt more quickly, as the CBD can be absorbed into the bloodstream more rapidly through the blood vessels under the tongue.
When using a topical form of CBD, such as a cream or lotion, the effects are typically localized to the area where it is applied and may be felt more quickly than when using oral forms of CBD.
It’s important to note that the effects of CBD can also be cumulative over time, meaning that regular use may result in more consistent and noticeable effects. Additionally, individual experiences with CBD can vary, so it’s important to monitor your own response and adjust the dosage as needed.
Recently I stumbled upon some research that I just had to share. If you are anything like me and like to treat yourself to an alcoholic beverage every now and then (or more than every now and then) and detest that nasty hangover, then this one’s for you…
Based on this research, I now vow to always consume Cannabinoids alongside my alcohol consumption to help mitigate negative effects.
We all are somewhat aware that alcohol is essentially poison, but let’s get into what it really does so we can understand how to combat its negative effects…
Alcohol has been shown to cause damage to the frontal and temporal lobes of the brain, in particular by inducing neuroinflammatory mediators and/or oxidative stress.These brain regions are known to be associated with problem solving, attention, information processing, learning, and memory.
Since CBD has neuroprotective effects that prevent oxidative damage, it has been considered for the treatment of cognitive impairments caused by alcohol. These effects of CBD have been hypothesized to be mediated by the 5HT1A (serotonin), or CB2 receptors.
These exciting results have been reported to support the potential therapeutic benefits of CBD for Alcohol Use Disorder, particularly in the areas of neurodegeneration, hepatotoxicity (chemical-driven liver damage), and cognition. Additionally, CBD can have a therapeutic effect in alcoholic liver diseases characterized by inflammation, oxidative stress, and steatosis (the abnormal retention of fat within a cell or organ).
There are several proposed mechanisms through which cannabinoids (and CBD in particular) may confer beneficial effects in the context of Alcohol Use Disorder (AUD). First, CBD may directly impact specific brain mechanisms underlying AUD to influence alcohol consumption and the clinical features of AUD.
Second, CBD may influence AUD symptoms through its actions across the digestive, immune, and central nervous systems, collectively known as the microbiota-gut-brain axis (MGBA). These MGBA disruptions have been associated with AUD symptoms such as craving and impaired cognitive control.
Furthermore, Preclinical data suggest that cannabinoids may confer beneficial effects on the gastrointestinal and immune system. These findings include reducing intestinal permeability, regulating gut bacteria, and reducing inflammation. Thus, cannabinoids may exert AUD harm-reduction effects, at least in part, through their beneficial actions across the MGBA.
Not to mention the effects alcohol has on dehydration. Electrolytes are what our bodies need to absorb water and remain hydrated. When people drink alcohol or caffeine, or exercise, not only do they become more dehydrated, but any water consumed after is not as effective due to a low balance of electrolytes. Insufficient electrolyte replenishment is a leading cause of why over 75 percent of people are chronically dehydrated.
With cannabis now legal in several U.S. states and industrialized hemp production legal nationwide, consumer curiosity in alternative forms of stress-release and relaxation is piqued. Whether it is tetrahydrocannabinol (THC), CBD, or other botanicals with purported relaxation benefits, consumers are interested in trying drinks that support their desire to slow down, market research firms say.
I hope you have learned from our research, like we have greatly. If you are one of these people looking to try alternative forms of stress-release, or just something to help balance out the negative effects of booze when you do choose to consume, take a look at our products.
Alzheimer’s disease is the leading cause of dementia accounting for 60% to 80% of all cases. The impairments of memory and thinking in Alzheimer’s disease have been linked to two abnormal features in the brain—amyloid plaques and neurofibrillary tangles. The damage associated with plaques and tangles leads to the death of neurons in regions essential to memory and thinking and eventually spreads to other areas of the brain as well.
For most people with Alzheimer’s disease, worsening problems with memory are the most prominent early symptom of the disease. Although people with Alzheimer’s are frequently able to recall events from many years ago, they have profound difficulty acquiring new memories. That’s partly because the hippocampus and other structures in the brain’s memory network are particularly vulnerable to the damage from Alzheimer’s disease. A person with dementia may ask a question, get an answer, then ask the same question a few minutes later. As we now know, dementia is a result of neurodegeneration; more specifically, the death of neurons that control memory and thinking.
The Endocannabinoid System takes part in the regulation of neurogenesis and neurodegeneration. Most studies suggest that endocannabinoid signaling is usually beneficial. The cannabinoid receptors CB1, CB2 and a protein coupled receptor GPR55 take part in the regulation of neurogenisis or neuronal rebuilding. Endocannabinoid signaling may also be beneficial because of its impact on halting neurotoxicity and neuroinflammation. It has been shown that deletion of CB1 accelerates brain aging through tumor necrosis factorα(TNF-α ), while CB1 binding decreases neuroinflammation.
The odd positive impact of ECS activation on cognitive enhancement may be also due to CB2 anti-inflammatory action or the impact of emotional state on learning and memory, all of which are modulated by ECS. Recent studies have shown CB2 presence in the central nervous system. In particular, it has been demonstrated that CB2 receptors are expressed in cells of the brain such as microglia, astrocytes and neurons in areas including the hippocampus, striatum and brain stem.
Noteworthily, it has been shown that CB2 receptors are largely distributed in activated astrocytes and microglia and thus they have an important role in the regulation of neuroinflammation when activated. CB2 activated receptors have an important role in the regulation of neuroinflammation.
Furthermore, it has been suggested that CB2 receptors could represent a promising therapeutic target in several neurodegenerative disorders, such as Alzheimer’s disease, Huntington’s disease, amyotrophic lateral sclerosis (ALS), and multiple sclerosis. In particular the activation of CB2 receptors might affect disease progression through the regulation of neurotransmission and neuronal function. Interestingly, the most largely studied mechanism of neuroprotection involves the anti-inflammatory effects of the CB2 receptors. This is of particular relevance considering that neuroinflammation is a crucial component of Dementia pathogenesis.
As the population ages and people live longer, dementia has become one of the most important health challenges in the world. The WHO estimates that around 50 million people have dementia worldwide and every year there are nearly 10 million new cases. The estimated proportion of the general population aged 60 and over with dementia at a given time is between 5–8%. The total number of people with dementia is projected to reach 82 million in 2030 and 152 in 2050.
Written by: Robin H. McDonald, RPh, is a registered pharmacist in Newport Beach, California. She received her B.S. from the University of Pittsburgh, School of Pharmacy, in 1991. She has enjoyed many facets of her career over the last 31 years. Including her retail pharmacy practice, she also has been an independent pharmacist, compounding pharmacist and a regional Pharmacy scheduler for a small retail pharmacy company in Birmingham, Alabama. Her interest in the health benefits of CBD oil was piqued when she became witness to the healing potential of CBD.
To this day, Robin has semi-retired from retail pharmacy practice which allows her to devote dedicated time to research and development into the expanding forefront of CBD oil and its benefits. Robin is also dedicating research to a broad range of botanical benefits, including CBD, for skincare purposes. Robin enjoys living in Newport Beach with her loving husband, Bill.
As we age, we can experience slower metabolism, increased likelihood of polypharmacy, cognitive decline and chronic physical/mental health problems.
CBD has no intoxicating effects or abuse liability, and because of its widespread activity in the Endocannabinoid System in the body, it has been proposed to be beneficial therapeutically for a variety of health conditions in people of all ages.
Generally, older adults suffer from more chronic medical and mental health conditions (eg, chronic pain, insomnia, and mood and cognitive disorders) than younger adults. Experts say CBD use will continue to gain momentum in the health and wellness world, with some scientific studies confirming it may ease symptoms of ailments like chronic pain, inflammation, and anxiety.
“Cannabinoids and Blood–Brain Barrier (BBB): The BBB works as an effective border between the Central Nervous System, and systemic circulation & microglia represents the main line of defense of the brain. When neuroinflammation occurs, the BBB protective function can be reduced by an inflammatory reaction from an immune-related cells involvement.
The BBB is prone to the consequences due to chronic systemic inflammation as it leads to brain inflammation and consequently can impair its integrity.
In this context, interest has grown about the cannabinoids as potential anti-inflammatory drugs. These findings suggest that CBD could be part of a new strategic approach useful to treat inflammatory diseases of [Central Nervous System] indicating that CBD might be useful for the positive modulation of the BBB as a future treatment in ischemic stroke.”
Diabetic Neuropathies (DPNs) is the most common complication associated with diabetes and is a leading cause of disability due to foot ulcerations, fall risks and can lead to infection and limb amputation.
CBD play roles in modulating neurotransmission and immune function.
When a nerve is injured or damaged, nociceptive (pain receptor) pathways and the immune system are affected, and the dysregulation of these neuroimmune processes has been associated with pain.
Topical CBD was found to help with both joint neuropathy and osteoarthritis by serving as a protectant to the nerves and reducing joint inflammation.
One of the reasons why using CBD oil topically is preferred for arthritis pain or neuropathy is because when applied topically, Cannabidiol has a direct and targeted impact on the affected body joints, muscles and nerves. In other words, topical CBD offers localized relief.
Shop our Topical Lab-Tested, Pharmacist Formulated Products such as our Golden Bee Hemp Pain Salve for Icy- Hot Rapid Relief!
