CBD molecules interact with the CB1 and CB2 receptors in the CNS, or the central nervous system and in the peripheral nervous system.
Interactions with these receptors prompt the release of serotonin. Medical research has shown that depressed persons exhibit lowered serotonin levels and therefore, it’s no secret that low serotonin leads to anxiety.
Treatment with CBD may also decrease the intensity and impact of symptoms commonly associated with PTSD, including chronic anxiety in stressful environments. Exposure to stress can trigger anxiety in PTSD patients and remind them of traumatic experiences. By reducing induced anxiety, CBD may help to regulate the negative effects associated with PTSD.
As we age, we can experience slower metabolism, increased likelihood of polypharmacy, cognitive decline and chronic physical/mental health problems.
CBD has no intoxicating effects or abuse liability, and because of its widespread activity in the Endocannabinoid System in the body, it has been proposed to be beneficial therapeutically for a variety of health conditions in people of all ages.
Generally, older adults suffer from more chronic medical and mental health conditions (eg, chronic pain, insomnia, and mood and cognitive disorders) than younger adults. Experts say CBD use will continue to gain momentum in the health and wellness world, with some scientific studies confirming it may ease symptoms of ailments like chronic pain, inflammation, and anxiety.
It is the duty of the healthcare professional to ask nonjudgmental assessment questions about Cannabis use, provide unbiased information, and help guide the patient to use it wisely. Physicians currently cannot prescribe CBD, however the better informed they are, the more they can help improve adherence to healthy behaviors.
As a doctor, important considerations for medicinal CBD use includes:
•Be open and non-judgmental in the dialogue with patients to keep communication open
• Be aware of the legal issues in your state • Provide legitimate and fair websites and clinical education to patients to research on their own
• Help patients be aware of drug to plant interactions, side effects and risks of addiction.
• Set goals and safety parameters if using CBD products
• Consider a treatment agreement
• Be mindful of addiction, abuse and mental health issues
As a patient, you should consider:
• Use a CBD product made from organically grown hemp
• Look for full or broad spectrum CBD
• Require transparency from your CBD company
• Keep CBD products out of reach of children
• Ask for test results and studies from manufacturers
• Utilize Independent Certifications when comparing product companies
• Look for companies that test for pesticides and heavy metals
Here, we report the case of a 20-year-old man with severe social anxiety disorder, major depressive disorder, insomnia and attenuated psychotic symptoms despite ongoing treatment with cognitive behavioral therapy and mirtazapine who was treated with adjunctive cannabidiol (CBD) in doses between 200 and 800 mg/day for 6 months.
During treatment with CBD, he experienced subjective benefits to his anxiety, depression and positive symptoms during treatment that were confirmed by clinicians and by standardized research instruments.
Findings from this case study add to existing evidence in support of the safety of CBD and suggest that it may be useful for young people with treatment refractory anxiety and for attenuated psychotic symptoms.
Treatment of social anxiety disorder and attenuated psychotic symptoms with cannabidiol Berger, Maximus; Li, Emily; Amminger, Günter Paul. BMJ Case Reports; London Vol. 13, Iss. 10, (Oct 2020). DOI:10.1136/bcr-2020-235307
“Cannabinoids and Blood–Brain Barrier (BBB): The BBB works as an effective border between the Central Nervous System, and systemic circulation & microglia represents the main line of defense of the brain. When neuroinflammation occurs, the BBB protective function can be reduced by an inflammatory reaction from an immune-related cells involvement.
The BBB is prone to the consequences due to chronic systemic inflammation as it leads to brain inflammation and consequently can impair its integrity.
In this context, interest has grown about the cannabinoids as potential anti-inflammatory drugs. These findings suggest that CBD could be part of a new strategic approach useful to treat inflammatory diseases of [Central Nervous System] indicating that CBD might be useful for the positive modulation of the BBB as a future treatment in ischemic stroke.”
Let’s Talk Terpenes! The many pleasant terpenes not only impart flavor and aroma, but also offer healing properties. These terpenes are widely represented elsewhere in nature in aromatic foods, spices, and tree resins, including broccoli, citrus fruits, mangoes, beer, basil, rosemary, cinnamon, and oregano. Here’s a quick overview:
🌿 Alpha-pinene terpenes are said to help enhance focus and memory. They are also thought to have bronchodilator, anti-inflammatory, and antimicrobial properties.
🌿 Linalool (lavender) is a sedative, anti-epileptic, and analgesic that also can help reduce anxiety.
🌿 Myrcene (mango) is analgesic, muscle-relaxing, and antibiotic.
🌿 Beta-caryophyllene (clove), known as the “happy” terpene, reduces anxiety, lifts spirits, and acts as an antioxidant and antimicrobial.
🌿 Limonene (lemon peel) improves mood, reduces anxiety and depression, and boosts immunity.
All True Natural Oils products contain large, quantifiable amounts of cannabinoids. This can be verified by looking at the independent lab test results posted on our website. It is very important to check lab reports before purchasing CBD products. We provide ours by scanning the QR code on the side of your box!
Terpenes extracted from cannabis offer a wide range of benefits when combined with CBD. In fact, when terpenes work together with CBD, they create a stronger effect. They deliver a richer experience by producing this synergistic phenomenon known as the Entourage Effect. Think of it as a treat to yourself!
To fully grasp this concept, think of human interactions in the business world. Some people have particular gifts or special abilities that allow them to excel in a subject or a field. Sometimes, these people meet other individuals who have a different set of skills. When alliances are formed between these two groups of people, and abilities are combined, progress can be made that were otherwise improbable.
Diabetic Neuropathies (DPNs) is the most common complication associated with diabetes and is a leading cause of disability due to foot ulcerations, fall risks and can lead to infection and limb amputation.
CBD play roles in modulating neurotransmission and immune function.
When a nerve is injured or damaged, nociceptive (pain receptor) pathways and the immune system are affected, and the dysregulation of these neuroimmune processes has been associated with pain.
Topical CBD was found to help with both joint neuropathy and osteoarthritis by serving as a protectant to the nerves and reducing joint inflammation.
One of the reasons why using CBD oil topically is preferred for arthritis pain or neuropathy is because when applied topically, Cannabidiol has a direct and targeted impact on the affected body joints, muscles and nerves. In other words, topical CBD offers localized relief.
Shop our Topical Lab-Tested, Pharmacist Formulated Products such as our Golden Bee Hemp Pain Salve for Icy- Hot Rapid Relief!
“Cannabiniol was the first Cannabinoid isolated from the Cannabis plant. The conversion process from THC to CBN can occur spontaneously in both Cannabis extracts and raw plant materials. CBN is a stable compound. It has a low affinity for the CB1 and CB2 cannabinoid receptors, but it is slightly higher for CB2. It is also an antagonist of the TPRM8 channels and a potent agonist of TRPA1. It has been described as a weak psychoactive compound. Studies have indicated the antibiotic, sedative, anti-inflammatory, and anticonvulsant effects of CBN.” Cannabis sativa L. as a Natural Drug Meeting the Criteria of a Multitarget Approach to Treatment International Journal of Molecular Sciences; Basel Vol. 22, Iss. 2, (2021)
True PM, which is high in CBN (cannabiniol), is gaining popularity as a natural alternative to help promote sleep and relaxation. Known as the “sleepy cannabinoid”, CBN naturally evolves from THC as it degrades or ages over time. Although it originates from THC, CBN is a separate cannabinoid and doesn’t have the psychoactive effects commonly associated with THC. For those interested in trying CBN, True PM makes the list of the best CBN oil products! All of our oils have extensive third-party lab testing and have received high marks from users of this product.
Autoimmune Diseases such as: Lupus, Psoriasis, Type 1 Diabetes, Rheumatoid Arthritis, Inflammatory Bowel Disease, etc. have shown to be linked to stress. For example, in this study citing a higher incidence of autoimmune diseases among people who were previously diagnosed with stress-related disorders. Another paper publishes:
“Physical and psychological stress has been implicated in the development of autoimmune disease, since numerous animal and human studies demonstrated the effect of sundry stressors on immune function. Moreover, many retrospective studies found that a high proportion (up to 80%) of patients reported uncommon emotional stress before disease onset.
It is presumed that the stress-triggered neuroendocrine hormones lead to immune dysregulation, which ultimately results in autoimmune disease, by altering or amplifying cytokine [inflammatory response] production. The treatment of autoimmune disease should thus include stress management and behavioral intervention to prevent stress-related immune imbalance. “
Because of CBD’s ability to combat stress levels (see previous blog post), it provides as a preventative measure and potential therapy for Autoimmune Disorders as a stress management tool.
**These statements have not been evaluated by the food and drug administration (FDA). These products are not intended to diagnose, treat, cure or prevent any disease. The information is not medical advice, and should not be treated as such.
Modern-day science continues to show the link between Stress & Disease. Stress can be defined as any experience that causes tension, whether that be physical, psychological, or emotional- and especially if it sets off the “fight or flight” response – during which the adrenal gland releases adrenaline, leading to rapid pulse and breathing, and increased blood pressure).
“Chronic stress result [in] failures of homeostasis, [and] thus lead to various diseases such as atherosclerosis, non-alcoholic fatty liver disease (NAFLD) and depression. However, while 75%–90% of human diseases is related to the activation of stress system, the common pathways between stress exposure and pathophysiological processes underlying disease is still debatable.
Chronic inflammation is an essential component of chronic diseases. Additionally, accumulating evidence suggested that excessive inflammation plays critical roles in the pathophysiology of the stress-related diseases, yet the basis for this connection is not fully understood.” this paper publishes.
In previous blog posts, we have spoken widely about CBD’s potential in regulating inflammation and returning the body to homeostasis. We have even shown how CBD acts in a similar way as antidepressants as it works on the serotonin (5HT)1a receptor. Serotonin deficiency is associated with depression and other psychiatric disorders, and it is likely that the effects CBD has on mood and anxiety are related to this interaction.