Posted on

CBD Benefits: Alcohol Consumption, Hangovers, and the Microbiota Gut-Brain Axis

Recently I stumbled upon some research that I just had to share. If you are anything like me and like to treat yourself to an alcoholic beverage every now and then (or more than every now and then) and detest that nasty hangover, then this one’s for you…

Based on this research, I now vow to always consume Cannabinoids alongside my alcohol consumption to help mitigate negative effects.

We all are somewhat aware that alcohol is essentially poison, but let’s get into what it really does so we can understand how to combat its negative effects…

Alcohol has been shown to cause damage to the frontal and temporal lobes of the brain, in particular by inducing neuroinflammatory mediators and/or oxidative stress. These brain regions are known to be associated with problem solving, attention, information processing, learning, and memory.

Since CBD has neuroprotective effects that prevent oxidative damage, it has been considered for the treatment of cognitive impairments caused by alcohol. These effects of CBD have been hypothesized to be mediated by the 5HT1A (serotonin), or CB2 receptors. 

These exciting results have been reported to support the potential therapeutic benefits of CBD for Alcohol Use Disorder, particularly in the areas of neurodegeneration, hepatotoxicity (chemical-driven liver damage), and  cognition.  Additionally, CBD can have a therapeutic effect in alcoholic liver diseases characterized by inflammation, oxidative stress, and steatosis (the abnormal retention of fat within a cell or organ).

There are several proposed mechanisms through which cannabinoids (and CBD in particular) may confer beneficial effects in the context of Alcohol Use Disorder (AUD). First, CBD may directly impact specific brain mechanisms underlying AUD to influence alcohol consumption and the clinical features of AUD.

Second, CBD may influence AUD symptoms through its actions across the digestive, immune, and central nervous systems, collectively known as the microbiota-gut-brain axis (MGBA). These MGBA disruptions have been associated with AUD symptoms such as craving and impaired cognitive control.

Furthermore, Preclinical data suggest that cannabinoids may confer beneficial effects on the gastrointestinal and immune system. These findings include reducing intestinal permeability, regulating gut bacteria, and reducing inflammation. Thus, cannabinoids may exert AUD harm-reduction effects, at least in part, through their beneficial actions across the MGBA.

Not to mention the effects alcohol has on dehydration. Electrolytes are what our bodies need to absorb water and remain hydrated. When people drink alcohol or caffeine, or exercise, not only do they become more dehydrated, but any water consumed after is not as effective due to a low balance of electrolytes.  Insufficient electrolyte replenishment is a leading cause of why over 75 percent of people are chronically dehydrated.

With cannabis now legal in several U.S. states and industrialized hemp production legal nationwide, consumer curiosity in alternative forms of stress-release and relaxation is piqued. Whether it is tetrahydrocannabinol (THC), CBD, or other botanicals with purported relaxation benefits, consumers are interested in trying drinks that support their desire to slow down, market research firms say.

I hope you have learned from our research, like we have greatly. If you are one of these people looking to try alternative forms of stress-release, or just something to help balance out the negative effects of booze when you do choose to consume, take a look at our products.

Shop Our Lab-Tested, Pharmacist- Formulated Full Spectrum Oils Now!

  • CBD Oils
  • Pet Products
  • Pain Salves
  • Lotion
  • Wound Care
  • Sleep Tinctures

Written by: Rylee Josipovich, Founder of Golden Bee Hemp & Robin H. McDonald, RPh, Research & Product Development Specialist for Natural Oils Inc.

Posted on

006 CBN & CBD for better Sleep with True PM with Robin, Research & Product Development Specialist

If you are ready to feel well rested and relaxed, then this is the podcast for you!

Exploring CBN as the “Mother” or “Sleepy” Cannabinoid, we discuss how these natural substances can help calm the body and the mind and help us drift off peacefully into dreamland!

We expel myths about CBD “being addictive,” and explore how these natural supplements can help the body in many ways to bring the body back to balance & homeostasis!

Hormones, Menopause, Melatonin Production, Mood, Seasonal Depression or “SADD” are also discussed in relation to CBD/CBN and as benefits from our products!

Listen in to find out how CBD can help you navigate Stress, Calm, Focus, Anxiety, Mood & more!

Article Robin was referencing:

“Therapeutic properties of multi-cannabinoid treatment strategies for Alzheimer’s disease

Frontiers in Neuroscience; Lausanne (Sep 2, 2022). DOI:10.3389/fnins.2022.962922”Coles, MadilynSteiner-Lim, Genevieve ZKarl,is  Tim.

Shop Our Lab-Tested, Pharmacist- Formulated Full Spectrum Oils Now!

  • CBD Oils
  • Pet Products
  • Pain Salves
  • Lotion
  • Wound Care
  • Sleep Tinctures

Posted on

CBD for Dementia: A Promising Therapeutic Agent for Neuroinflammation

Alzheimer’s disease is the leading cause of dementia accounting for 60% to 80% of all cases. The impairments of memory and thinking in Alzheimer’s disease have been linked to two abnormal features in the brain—amyloid plaques and neurofibrillary tangles. The damage associated with plaques and tangles leads to the death of neurons in regions essential to memory and thinking and eventually spreads to other areas of the brain as well. 

For most people with Alzheimer’s disease, worsening problems with memory are the most prominent early symptom of the disease. Although people with Alzheimer’s are frequently able to recall events from many years ago, they have profound difficulty acquiring new memories. That’s partly because the hippocampus and other structures in the brain’s memory network are particularly vulnerable to the damage from Alzheimer’s disease. A person with dementia may ask a question, get an answer, then ask the same question a few minutes later. As we now know, dementia is a result of neurodegeneration; more specifically, the death of neurons that control memory and thinking.

The Endocannabinoid System takes part in the regulation of neurogenesis and neurodegeneration. Most studies suggest that endocannabinoid signaling is usually beneficial. The cannabinoid receptors CB1, CB2 and a protein coupled receptor GPR55 take part in the regulation of neurogenisis or neuronal rebuilding.   Endocannabinoid signaling may also be beneficial because of its impact on halting neurotoxicity and neuroinflammation. It has been shown that deletion of CB1 accelerates brain aging through tumor necrosis factorα(TNF-α ), while CB1 binding decreases neuroinflammation. 

The odd positive impact of ECS activation on cognitive enhancement may be also due to CB2 anti-inflammatory action or the impact of emotional state on learning and memory, all of which are modulated by ECS. Recent studies have shown CB2 presence in the central nervous system.  In particular, it has been demonstrated that CB2 receptors are expressed in cells of the brain such as microglia, astrocytes and neurons in areas including the hippocampus, striatum and brain stem.

Noteworthily, it has been shown that CB2 receptors are largely distributed in activated astrocytes and microglia and thus they have an important role in the regulation of neuroinflammation when activated.  CB2 activated receptors have an important role in the regulation of neuroinflammation.

Furthermore, it has been suggested that CB2 receptors could represent a promising therapeutic target in several neurodegenerative disorders, such as Alzheimer’s disease, Huntington’s disease, amyotrophic lateral sclerosis (ALS), and multiple sclerosis. In particular the activation of CB2 receptors might affect disease progression through the regulation of neurotransmission and neuronal function. Interestingly, the most largely studied mechanism of neuroprotection involves the anti-inflammatory effects of the CB2 receptors.  This is of particular relevance considering that neuroinflammation is a crucial component of Dementia pathogenesis. 

As the population ages and people live longer, dementia has become one of the most important health challenges in the world. The WHO estimates that around 50 million people have dementia worldwide and every year there are nearly 10 million new cases. The estimated proportion of the general population aged 60 and over with dementia at a given time is between 5–8%. The total number of people with dementia is projected to reach 82 million in 2030 and 152 in 2050.

REF:

Basile MS, Mazzon E. The Role of Cannabinoid Type 2 Receptors in Parkinson’s Disease. Biomedicines. 2022 Nov 20;10(11):2986. doi: 10.3390/biomedicines10112986. PMID: 36428554; PMCID: PMC9687889.

Galve-Roperh I, Palazuelos J, Aguado T, Guzmán M. The endocannabinoid system and the regulation of neural development: potential implications in psychiatric disorders. Eur Arch Psychiatry Clin Neurosci. 2009 Oct;259(7):371-82. doi: 10.1007/s00406-009-0028-y. Epub 2009 Jul 9. PMID: 19588184.

Shop Our Lab-Tested, Pharmacist- Formulated Full Spectrum Oils Now!

  • CBD Oils
  • Pet Products
  • Pain Salves
  • Lotion
  • Wound Care
  • Sleep Tinctures

Written by: Robin H. McDonald, RPh, is a registered pharmacist in Newport Beach, California. She received her B.S. from the University of Pittsburgh, School of Pharmacy, in 1991. She has enjoyed many facets of her career over the last 31 years. Including her retail pharmacy practice, she also has been an independent pharmacist, compounding pharmacist and a regional Pharmacy scheduler for a small retail pharmacy company in Birmingham, Alabama. Her interest in the health benefits of CBD oil was piqued when she became witness to the healing potential of CBD. 

To this day, Robin has semi-retired from retail pharmacy practice which allows her to devote dedicated time to research and development into the expanding forefront of CBD oil and its benefits.  Robin is also dedicating research to a broad range of botanical benefits, including CBD, for skincare purposes.  Robin enjoys living in Newport Beach with her loving husband, Bill. 

Posted on

CBD for Dog Cancer: Supported by Clinical Studies

The use of CBD products for pets, namely dogs and cats, has been widely adopted for its benefits in aiding with inflammation, cancer, and the other health issues that arise from aging in animals.

The benefits of CBD in the “frosted faces” of our loved ones is easily noticeable, as many pets experience an increase of energy, a decrease of aggression, limp a little less, and overall experience better quality of life.

….at least these experiences are among the reviews we have gotten from our pet CBD products.

While clinic research is still lacking surrounding hemp products, there is always a constant trickling in of new studies that point to just how promising hemp is to health and wellness, including one that was just released called:

The effect of cannabidiol on canine neoplastic cell proliferation and mitogen-activated protein kinase activation during autophagy and apoptosis

(In layman terms, the effect of CBD (CannaBiDiol) on abnormal growths/ cancer and cell death and recyclying)

“The objectives of our study were to explore the anti-proliferative and cell death response associated with in vitro treatment of canine cancer cell lines with CBD alone and combination with common chemotherapeutics, as well as investigation into major proliferative pathways”

….”In conclusion, CBD is effective at hindering cell proliferation and induction of autophagy and apoptosis rapidly across neoplastic cell lines and further clinical trials are needed to understand its efficacy and interactions with traditional chemotherapy.”

https://pubmed.ncbi.nlm.nih.gov/33247539/

While there still remains much to be discovered surrounding hemp products, there is no denying the real-life first hand experiences of those touting the benefits of CBD. Furthermore, with frequent scientific studies such as this one showing the promise of Hemp, and the lack of side effects of Hemp, the question of “what is there to lose?” is proposed in the face of battling cancer.

Shop Our Lab-Tested, Pharmacist- Formulated Full Spectrum Oils Now!

  • CBD Oils
  • Pet Products
  • Pain Salves
  • Lotion
  • Wound Care
  • Sleep Tinctures
Posted on

New Product! First- Aid Essential: Manuka ~Whipped~ Body Butter! 2750 mg CBD / CBG

Whipped Aloe, Jojoba, Lemongrass, Lavender Base

We at True Natural Oils have brought you a luxurious, whipped treat for your body that is also naturally healing and a joy for the senses!

Introducing – Manuka Butter!

Manuka is a miraculous extract, as it is a relative to Tea Tree Oil with many antifungal, antiviral, and antibacterial qualities.

It is commonly used to treat Skin Conditions such as:

-Itchiness
-Rashes
-Bug bites
-Eczema
-Wounds & cuts
-Dry Patches
-Burns

Manuka is also ultra hydrating, and fights wrinkles and fine lines with its antioxidant power!! This is why we have chosen to pair it with Aloe Vera, Jojoba, Lemongrass, Lavender and anti-inflammatory Broad Spectrum Cannabinoids like CBD & CBG for a truly multipurpose formula!

Use this delicate blend of herbal extracts to treat, soothe and nourish all areas of the skin! With a natural fragrance so delicious, you may forget all about the medicinal qualities!

Shop now to give your skin & senses a well-deserved soothing treat!

ALSO AVAILABLE FOR PETS!

Posted on

New Podcast Episode “Let’s Talk About CBD” with Pam Sheets, Dog Sports Trainer & Maker of Wild Raw Meals for Dogs!

Pam Sheets is considered an expert in her field for her knowledge on training dogs and keeping them Healthy! She prioritizes Dog Health, and has compiled a raw multi-protein meal recipe complete with vegetation she grows in her own garden!

Pam is an avid proponent of supplementing with Natural Pet Oil for her dogs, and uses our Human lines for herself and all of her family members!

Enjoy this talk with Pam as she talks to us about dog sports, walks us through the benefits she has seen from using our products, and even details how she got her mom off of daily painkillers and onto CBD for treating her pain!

Pam’s Website: https://www.wilddogssports.com/

Find us on SPOTIFY at: https://open.spotify.com/show/1D1wNd0ew0imsez3tR3DMR
Find us on APPLE PODCASTS at: https://podcasts.apple.com/us/podcast/lets-talk-about-cbd/id1639848427

Shop Our Lab-Tested, Pharmacist- Formulated Full Spectrum Oils Now!

  • CBD Oils
  • Pet Products
  • Pain Salves
  • Lotion
  • Wound Care
  • Sleep Tinctures

Posted on

FAQ: How Could CBD Help with PTSD?

 CBD molecules interact with the CB1 and CB2 receptors in the CNS, or the central nervous system and in the peripheral nervous system.

Interactions with these receptors prompt the release of serotonin. Medical research has shown that depressed persons exhibit lowered serotonin levels and therefore, it’s no secret that low serotonin leads to anxiety.

Treatment with CBD may also decrease the intensity and impact of  symptoms commonly associated with PTSD, including chronic anxiety in stressful environments.  Exposure to stress can trigger anxiety in PTSD patients and remind them of traumatic experiences. By reducing induced anxiety, CBD may help to regulate the negative effects associated with PTSD.

(The above is not medical advice.)

Shop Our Lab-Tested, Pharmacist- Formulated Full Spectrum Oils Now!

Posted on

FAQ: How Can CBD help in Aging?

As we age, we can experience slower metabolism, increased likelihood of polypharmacy, cognitive decline and chronic physical/mental health problems.

CBD has no intoxicating effects or abuse liability, and because of its widespread activity in the Endocannabinoid System in the body, it has been proposed to be beneficial therapeutically for a variety of health conditions in people of all ages.

Generally, older adults suffer from more chronic medical and mental health conditions (eg, chronic pain, insomnia, and mood and cognitive disorders) than younger adults.  Experts say CBD use will continue to gain momentum in the health and wellness world, with some scientific studies confirming it may ease symptoms of ailments like chronic pain, inflammation, and anxiety.

Shop Our Lab-Tested, Pharmacist- Formulated Full Spectrum Oils Now!

  • CBD Oils
  • Pet Products
  • Pain Salves
  • Lotion
  • Wound Care
  • Sleep Tinctures
Posted on

FAQ: How can I talk to my Doctor about CBD?

It is the duty of the healthcare professional to ask nonjudgmental assessment questions about Cannabis use, provide unbiased information, and help guide the patient to use it wisely. Physicians currently cannot prescribe CBD, however the better informed they are, the more they can help improve adherence to healthy behaviors.

As a doctor, important considerations for medicinal CBD use includes:

•Be open and non-judgmental in the dialogue with patients to keep communication open

• Be aware of the legal issues in your state • Provide legitimate and fair websites and clinical education to patients to research on their own

 • Help patients be aware of drug to plant interactions, side effects and risks of addiction. 

• Set goals and safety parameters if using CBD products 

• Consider a treatment agreement

 • Be mindful of addiction, abuse and mental health issues 


As a patient, you should consider:

• Use a CBD product made from organically grown hemp

• Look for full or broad spectrum CBD

• Require transparency from your CBD company 

• Keep CBD products out of reach of children 

• Ask for test results and studies from manufacturers 

• Utilize Independent Certifications when comparing product companies

 • Look for companies that test for pesticides and heavy metals

*Not Medical Advice

Shop Our Lab-Tested, Pharmacist- Formulated Full Spectrum Oils Now!

  • CBD Oils
  • Pet Products
  • Pain Salves
  • Lotion
  • Wound Care
  • Sleep Tinctures
Posted on

FAQ: How Could CBD help my Social Anxiety?

Here, we report the case of a 20-year-old man with severe social anxiety disorder, major depressive disorder, insomnia and attenuated psychotic symptoms despite ongoing treatment with cognitive behavioral therapy and mirtazapine who was treated with adjunctive cannabidiol (CBD) in doses between 200 and 800 mg/day for 6 months.

During treatment with CBD, he experienced subjective benefits to his anxiety, depression and positive symptoms during treatment that were confirmed by clinicians and by standardized research instruments.

Findings from this case study add to existing evidence in support of the safety of CBD and suggest that it may be useful for young people with treatment refractory anxiety and for attenuated psychotic symptoms.

Treatment of social anxiety disorder and attenuated psychotic symptoms with cannabidiol Berger, Maximus; Li, Emily; Amminger, Günter Paul. BMJ Case Reports; London Vol. 13, Iss. 10, (Oct 2020). DOI:10.1136/bcr-2020-235307

Shop Our Lab-Tested, Pharmacist- Formulated Full Spectrum Oils Now!

  • CBD Oils
  • Pet Products
  • Pain Salves
  • Lotion
  • Wound Care
  • Sleep Tinctures