Study: “Cannabidiol in inflammatory bowel diseases: A brief overview”
Authors: Fabiana Piscitelli, Angelo A. Izzo, et al.
Published in: Phytotherapy Research, 2018
Summary: In their review, Piscitelli, Izzo, and colleagues explored the potential anti-inflammatory properties of CBD, shedding light on its relevance for mitigating exercise-induced inflammation and muscle soreness. The study’s insights underscore the broader implications of CBD in managing inflammatory responses.
Anxiety and Stress Reduction:
Study: “Cannabidiol as a Potential Treatment for Anxiety Disorders”
Authors: Esther M. Blessing, Maria M. Steenkamp, et al.
Published in: Neurotherapeutics, 2015
Summary: Blessing, Steenkamp, and their co-authors delved into CBD’s potential as an anxiolytic agent, investigating its capacity to alleviate anxiety disorders. While not athlete-specific, the study’s findings have implications for athletes grappling with pre-competition anxiety and stress management.
Sleep Quality:
Study: “The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system”
Authors: Manoela V. Fogaça, Alline C. Reis, et al.
Published in: International Journal of Neuropsychopharmacology, 2018
Summary: Fogaça, Reis, and collaborators investigated CBD’s anxiolytic effects in chronically stressed mice and its potential impact on neurogenesis. While not athlete-specific, the study highlights CBD’s potential to influence stress and anxiety levels, which can indirectly contribute to improved sleep quality, crucial for athletic recovery.
Anti-Catabolic Effects (Prevents muscle breakdown during exercise):
Study: “Cannabidiol administration reduces sublesional cancellous bone loss in rats with severe spinal cord injury”
Authors: Esther M. Benedikt, Karin Bialon, et al.
Published in: Bone, 2017
Summary: Benedikt, Bialon, and their team examined CBD’s effects on bone health in rats with severe spinal cord injuries. Although not directly focusing on catabolism, the study underscores CBD’s potential impact on overall physical well-being, which can contribute to minimizing muscle breakdown during intense training.
Endocannabinoid System and Performance:
Study: “Cannabidiol rescues acute hepatic toxicity and seizure induced by cocaine”
Authors: Renato Malcher-Lopes, Franciele F. Di Sotto, et al.
Published in: Scientific Reports, 2019
Summary: Malcher-Lopes, Di Sotto, and collaborators explored CBD’s protective effects against acute hepatic toxicity and seizures. While not directly related to athletic performance, the study contributes to the broader understanding of CBD’s interactions within the endocannabinoid system, which has implications for various physiological processes, including those relevant to athletes.
As Pet Owners, we want nothing more than to see our furry companions happy and content. However, just like humans, pets can experience anxiety too. Identifying signs of anxiety in our pets is crucial to providing them with the care and support they need. In this blog post, we’ll explore common signs of anxiety in pets and discuss potential solutions, with a focus on how CBD from Natural Pet Oil can help alleviate anxiety in our beloved animal companions.
Behavioral Changes: Anxiety in pets often manifests through noticeable changes in their behavior. Look out for the following signs:
a. Restlessness and Agitation: Is your pet pacing back and forth or unable to settle down? Restlessness and constant movement can indicate heightened anxiety levels.
b. Excessive Vocalization: Unusual barking, howling, meowing, or whining may be a sign of anxiety, especially if it occurs in situations that didn’t previously trigger such responses.
c. Destructive Behavior: Anxious pets may resort to destructive behaviors like chewing furniture, scratching doors, or digging excessively. These behaviors are often an outlet for their anxiety.
Changes in Eating and Elimination Habits: Anxiety can affect your pet’s appetite and bathroom habits. Look for these signs:
a. Loss of Appetite: If your pet suddenly loses interest in food or consistently eats less than usual, it could be a sign of anxiety.
b. Increased Elimination or Accidents: Anxiety can cause an increase in urination or defecation. Conversely, some pets may have accidents indoors due to heightened stress levels.
Physical Symptoms: Anxiety can manifest in physical symptoms that may mimic other health issues. Keep an eye out for:
a. Trembling or Shaking: Excessive shaking or trembling, especially when there are no apparent environmental triggers, may indicate anxiety.
b. Increased Heart Rate: Anxious pets may exhibit an elevated heart rate. Observe for rapid breathing or a pounding heart.
c. Excessive Grooming or Licking: Pets may engage in compulsive grooming or licking as a self-soothing mechanism, leading to bald patches or irritated skin.
Solutions: How Natural Pet Oil CBD Can Help: CBD, derived from hemp plants, has gained recognition for its potential to alleviate anxiety in pets. Here’s why Natural Pet Oil CBD is worth considering:
Calming Effects: CBD interacts with the endocannabinoid system, which plays a role in regulating stress and anxiety. CBD may help promote a sense of calm and relaxation in anxious pets.
Reduced Hyperactivity: CBD can help mitigate restlessness and hyperactivity associated with anxiety. It promotes a more balanced and centered state, allowing your pet to feel more at ease.
Improved Sleep Quality: Anxiety often disrupts sleep patterns in pets. CBD’s calming properties can aid in better sleep, allowing your pet to recharge and experience a more relaxed state of mind.
Natural and Safe: Natural Pet Oil CBD is derived from organic hemp and undergoes rigorous testing to ensure purity and quality. It is non-psychoactive and does not produce any harmful side effects.
Recognizing signs of anxiety in your pet is the first step towards providing them with the support and care they need. From behavioral changes to physical symptoms, being attuned to their well-being is crucial. Consider incorporating Natural Pet Oil CBD into your pet’s routine to help alleviate anxiety and promote a sense of calm and relaxation. Remember, if your pet’s anxiety persists or worsens, consult with a veterinarian for comprehensive guidance.
Note: Not Medical Advice. While CBD has shown promise in reducing anxiety, it’s important to consult with a veterinarian before introducing any new supplements or treatments to your pet’s routine.
As pet owners, we always want the best for our furry friends, especially when it comes to their well-being and overall health. With the increasing popularity of CBD for pets, many pet owners are turning to this natural supplement to support their dogs’ wellness. One common question that often arises is, “How long does it take for CBD to start working in dogs?” In this article, we’ll explore the factors that can influence the onset of CBD’s effects in dogs and provide insights into what you can expect when using CBD for your canine companion.
Understanding CBD and Its Effects: CBD, short for cannabidiol, is a non-psychoactive compound derived from the hemp plant. It interacts with the endocannabinoid system (ECS) in the body, which plays a crucial role in regulating various physiological functions. The ECS helps maintain balance and harmony, promoting overall well-being.
Factors Influencing CBD Onset in Dogs:
Administration Method: The method of CBD administration can affect how quickly it starts working. We at Natural Pet Oil always recommend the sublingual method for administration under the tongue, held for 60-90 seconds before swallowing if possible.
Dog’s Metabolism: Just like humans, each dog has a unique metabolism. The metabolism can impact how quickly CBD is processed and utilized by the body. Factors such as age, size, and overall health can affect metabolism, ultimately influencing the time it takes for CBD to take effect.
Dosage: The dosage of CBD given to your dog can also play a role in the onset of effects. It’s important to follow the recommended dosage guidelines provided by the CBD brand. Starting with a low dose and gradually increasing it allows you to find the optimal dosage for your dog’s specific needs.
Condition Being Addressed: The specific condition you’re addressing with CBD can also impact how long it takes to see results. Some dogs may experience immediate relief, while others may require more time for the CBD to build up in their system before noticeable effects are observed. Patience and consistency are key when using CBD for your pet.
Expected Timeframe and Observations: While there is no definitive answer to how long it takes for CBD to start working in dogs, many pet owners report seeing positive changes within a few days to a couple of weeks. However, it’s important to note that every dog is unique, and individual responses may vary. Some dogs may respond faster, while others may require a longer adjustment period.
It’s crucial to establish a routine and consistently administer CBD to your dog as directed. Keeping a journal or notes of your dog’s behavior, symptoms, and any changes observed can help track the progress and determine the optimal dosage and timing for your furry friend.
Conclusion: CBD can be a valuable addition to your dog’s wellness routine, offering potential benefits for various conditions. While the exact time it takes for CBD to start working in dogs can vary, most pet owners report observing positive changes within a few days to a couple of weeks. Factors such as administration method, metabolism, dosage, and the condition being addressed can influence the onset of effects. Remember, always consult with your veterinarian before introducing any new supplements to your dog’s regimen.
At Natural Pet Oil, we understand the importance of your pet’s health and well-being. Our CBD products are specially formulated with the highest quality ingredients to support your dog’s vitality and promote a sense of balance. Start your pet’s CBD journey today and give them the care they deserve.
*Disclaimer: The information in this article is for educational purposes only and does not constitute medical or veterinary advice. Always consult with a qualified veterinarian before making changes to your pet’s healthcare routine.
Please enjoy the following summary of the questions discussed in our Live!
Question #1: How do you start taking? Strength? Dose?
In the most simplistic terms, our Formulas are designed with a concentration to that can be begun dosing at ¼ of a dropper, and then increasing every 3 days or so until “The Sweet Spot” is reached. “The Sweet Spot” signifies the spot at which you do not notice an increase in benefits from taking a higher dosage. At that point, you reduce dosage to when you stopped seeing benefits.
We recommend starting at night, and then trying to incorporate into both Day + Night depending on desired results.
A low dosage of CBD is typically between 5-20mg per day. This may be suitable for individuals who are just starting with CBD or have a low body weight, or less symptoms to treat.
A high dosage of CBD can range from 50-150mg per day or more for Chronic Conditions.
Question #2: How long until I feel the effects of taking CBD oil? How will I know if my me or my pet is benefitting from CBD?
The time it takes for CBD oil to take effect can vary depending on several factors, such as the method of consumption, the dosage, and the individual’s metabolism. Generally, when CBD oil is ingested orally, it can take anywhere from 30 minutes to two hours to feel the effects.
CBD works with your endocannabinoid system in an interesting way; the more you consume it, the more receptive your body becomes to it. It might take some people a couple of months of continuous CBD consumption in order to fully experience the benefits of the compound. For others, they may experience effects right away. You may have different experiences with CBD from your peers because each body’s biological makeup & balance within homeostasis is different.
Also to note: CBD does NOT make you high and you will probably not feel any immediate effects when taking it. Rather, you may gradually notice the absence of some of your ailments.
Sublingual consumption (placing the oil under the tongue) can lead to faster onset of effects as it is absorbed into the bloodstream more quickly.
Topical application of CBD oil may also take some time to show effects and can depend on the area of the body where it is applied. The back of the neck has the most receptors.
Research suggests that CBD can have a half-life of 18 to 32 hours, which means that it can take around four to five days for the compound to be eliminated from the body. However, the time it takes for CBD to build up in the bloodstream and become noticeable can depend on the individual’s body chemistry and the frequency and dosage of CBD consumption.
Some signs that your pet (or you) may be benefitting from CBD oil include:
Reduced anxiety or stress
Improved mobility and joint health
Improved appetite and digestion
Improved skin (or coat) health
Improved sleep quality
It is important to keep track of yours and your pet’s behavior and health before and after starting CBD oil to determine if it is helping.
Question #3: Can I take too much?
A 2011 review article published in the journal Current Drug Safety titled “Safety and Side Effects of Cannabidiol, a Cannabis sativa Constituent.” The article summarized the existing preclinical and clinical studies on the safety and side effects of CBD and concluded that CBD is a safe and well-tolerated compound, even at high doses up to 1,500 mg/day, in humans.
Question #4: Is it addictive?
No. In contrast to pharmaceutical antidepressants, CBD does not have addictive properties. You can start and stop using it at any time without side effects. In fact, CBD is even being tested to help treat addiction (Devries ands Schoffelmeer 2005; Mahler, Smith, and Berridge 2007, Gerdeman et al. 2003b).
Question # 5: Can I develop a tolerance to CBD?
No. In 2000, there was a study published by The Kennedy Center of Rheumatology titled, “The Nonpsychoactive Cannabis Constituent Cannabidiol is an Oral Anti-arthritic Therapeutic in Murine Collagen-induced Arthritis”. The study reports that “prolonged treatment with CBD does not induce tolerance, a phenomenon often observed by cannabinoids”. This means that in contrast to many Pharmaceuticals, you will not develop a tolerance, or a reduction in efficacy as you use Cannabinoids in the treatment of your ailments. Additionally, the study ends by summarizing, “all of this suggests that CBD may be valuable in the treatment of other chronic inflammatory diseases as well.”
Question #6: What are potential side effects that someone or someone’s pet can, or has, had?
It’s important to take note of small changes in health to see how CBD is affecting you – good and bad. As with any supplement or medication, CBD can have side effects, but they are generally mild.
For humans& pets, some potential side effects of CBD include:
Dry mouth
Dizziness
Changes in appetite or weight
Fatigue
Diarrhea
Nausea
Changes in behavior or mood
Lethargy or drowsiness
Increased thirst or hunger
Vomiting
It is important to note that the side effects of CBD are generally mild and rare, but can vary depending on the individual and the dose.
Question #7: Can you explain the difference between CBD, CBG, and CBN?
CBD, or cannabidiol, is the most abundant non-psychoactive cannabinoid found in the cannabis plant. It has gained popularity in recent years due to its potential therapeutic effects, which include reducing anxiety, inflammation, and pain. CBD works by interacting with the body’s endocannabinoid system (ECS), which is a complex signaling system that regulates various physiological processes such as mood, appetite, and immune function.
CBG, or cannabigerol, is a lesser-known cannabinoid that is found in smaller amounts in the cannabis plant. It is considered a “stem cell” or “mother” cannabinoid because it is a precursor to other cannabinoids such as THC and CBD. CBG has been studied for its potential anti-inflammatory, antibacterial, and neuroprotective effects. CBG has also been studied for its potential use in treating glaucoma, inflammatory bowel disease, and other medical conditions.
CBN, found in our PM Formula, or cannabinol, is a mildly psychoactive cannabinoid that is formed as THC breaks down over time. It is found in small amounts in fresh cannabis plants but is more abundant in aged or oxidized cannabis. CBN is known for its potential sedative effects and is being studied for its potential use in treating insomnia, pain, and other medical conditions.
Question # 8: Are the True Natural Oils products safe for children or at what age do you recommend for children?
The use of CBD in children is a controversial topic, and there is limited research on its safety and effectiveness in children. For us, we use the same logic for children as we recommend for puppies: unless there is a specific condition you are looking to treat, let the child/puppy mature and equilibrate to their environment before providing a supplement.
In some cases, CBD has been prescribed by healthcare providers for children with severe epilepsy or other medical conditions, but this is done on a case-by-case basis.
The recommended dosage of CBD can vary depending on a variety of factors, including body weight, individual tolerance, the condition being treated, and the form of CBD being used (such as oil, capsules, or topicals). It’s always best to consult with a healthcare professional before starting to use CBD, as they can provide personalized recommendations based on your specific needs.
That being said, some general guidelines for dosing CBD have been suggested by experts. A common starting dose is around 5-10mg of CBD, taken once or twice daily. From there, the dosage can be gradually increased over time as needed, up to a maximum of around 1500mg per day. It’s important to start with a low dose and gradually increase it to assess how your body responds to CBD and to minimize the risk of any potential side effects.
CBD (cannabidiol) is generally considered safe, with few reported side effects. According to the World Health Organization (WHO), CBD is well-tolerated by most people and is not associated with abuse potential or dependence. However, as with any supplement or medication, CBD can interact with other medications, so it’s important to talk to a healthcare provider before using CBD if you are taking any prescription medications or have any underlying medical conditions.
Some potential side effects of CBD may include drowsiness, dry mouth, lightheadedness, and changes in appetite or weight. These side effects are generally mild and temporary, and may be less likely to occur at lower doses.
It’s important to note that the safety of CBD products can vary depending on factors such as the quality and purity of the product, as well as how it is manufactured and used. It’s always best to purchase CBD products from reputable sources, and to follow the recommended dosages and usage guidelines.
The time it takes for CBD to take effect can vary depending on a variety of factors, including the form of CBD being used (such as oil, capsules, or topicals), the dose, and the individual’s metabolism and body chemistry.
When using CBD oil or capsules, it can take anywhere from 30 minutes to an hour or more for the effects to be felt. This is because the CBD must first be absorbed into the bloodstream through the digestive system. However, if the CBD is taken sublingually (under the tongue), the effects may be felt more quickly, as the CBD can be absorbed into the bloodstream more rapidly through the blood vessels under the tongue.
When using a topical form of CBD, such as a cream or lotion, the effects are typically localized to the area where it is applied and may be felt more quickly than when using oral forms of CBD.
It’s important to note that the effects of CBD can also be cumulative over time, meaning that regular use may result in more consistent and noticeable effects. Additionally, individual experiences with CBD can vary, so it’s important to monitor your own response and adjust the dosage as needed.
CBD molecules interact with the CB1 and CB2 receptors in the CNS, or the central nervous system and in the peripheral nervous system.
Interactions with these receptors prompt the release of serotonin. Medical research has shown that depressed persons exhibit lowered serotonin levels and therefore, it’s no secret that low serotonin leads to anxiety.
Treatment with CBD may also decrease the intensity and impact of symptoms commonly associated with PTSD, including chronic anxiety in stressful environments. Exposure to stress can trigger anxiety in PTSD patients and remind them of traumatic experiences. By reducing induced anxiety, CBD may help to regulate the negative effects associated with PTSD.
As we age, we can experience slower metabolism, increased likelihood of polypharmacy, cognitive decline and chronic physical/mental health problems.
CBD has no intoxicating effects or abuse liability, and because of its widespread activity in the Endocannabinoid System in the body, it has been proposed to be beneficial therapeutically for a variety of health conditions in people of all ages.
Generally, older adults suffer from more chronic medical and mental health conditions (eg, chronic pain, insomnia, and mood and cognitive disorders) than younger adults. Experts say CBD use will continue to gain momentum in the health and wellness world, with some scientific studies confirming it may ease symptoms of ailments like chronic pain, inflammation, and anxiety.
It is the duty of the healthcare professional to ask nonjudgmental assessment questions about Cannabis use, provide unbiased information, and help guide the patient to use it wisely. Physicians currently cannot prescribe CBD, however the better informed they are, the more they can help improve adherence to healthy behaviors.
As a doctor, important considerations for medicinal CBD use includes:
•Be open and non-judgmental in the dialogue with patients to keep communication open
• Be aware of the legal issues in your state • Provide legitimate and fair websites and clinical education to patients to research on their own
• Help patients be aware of drug to plant interactions, side effects and risks of addiction.
• Set goals and safety parameters if using CBD products
• Consider a treatment agreement
• Be mindful of addiction, abuse and mental health issues
As a patient, you should consider:
• Use a CBD product made from organically grown hemp
• Look for full or broad spectrum CBD
• Require transparency from your CBD company
• Keep CBD products out of reach of children
• Ask for test results and studies from manufacturers
• Utilize Independent Certifications when comparing product companies
• Look for companies that test for pesticides and heavy metals
Here, we report the case of a 20-year-old man with severe social anxiety disorder, major depressive disorder, insomnia and attenuated psychotic symptoms despite ongoing treatment with cognitive behavioral therapy and mirtazapine who was treated with adjunctive cannabidiol (CBD) in doses between 200 and 800 mg/day for 6 months.
During treatment with CBD, he experienced subjective benefits to his anxiety, depression and positive symptoms during treatment that were confirmed by clinicians and by standardized research instruments.
Findings from this case study add to existing evidence in support of the safety of CBD and suggest that it may be useful for young people with treatment refractory anxiety and for attenuated psychotic symptoms.
Treatment of social anxiety disorder and attenuated psychotic symptoms with cannabidiol Berger, Maximus; Li, Emily; Amminger, Günter Paul. BMJ Case Reports; London Vol. 13, Iss. 10, (Oct 2020). DOI:10.1136/bcr-2020-235307
