CBD molecules interact with the CB1 and CB2 receptors in the CNS, or the central nervous system and in the peripheral nervous system.
Interactions with these receptors prompt the release of serotonin. Medical research has shown that depressed persons exhibit lowered serotonin levels and therefore, it’s no secret that low serotonin leads to anxiety.
Treatment with CBD may also decrease the intensity and impact of symptoms commonly associated with PTSD, including chronic anxiety in stressful environments. Exposure to stress can trigger anxiety in PTSD patients and remind them of traumatic experiences. By reducing induced anxiety, CBD may help to regulate the negative effects associated with PTSD.
“Cannabiniol was the first Cannabinoid isolated from the Cannabis plant. The conversion process from THC to CBN can occur spontaneously in both Cannabis extracts and raw plant materials. CBN is a stable compound. It has a low affinity for the CB1 and CB2 cannabinoid receptors, but it is slightly higher for CB2. It is also an antagonist of the TPRM8 channels and a potent agonist of TRPA1. It has been described as a weak psychoactive compound. Studies have indicated the antibiotic, sedative, anti-inflammatory, and anticonvulsant effects of CBN.” Cannabis sativa L. as a Natural Drug Meeting the Criteria of a Multitarget Approach to Treatment International Journal of Molecular Sciences; Basel Vol. 22, Iss. 2, (2021)
True PM, which is high in CBN (cannabiniol), is gaining popularity as a natural alternative to help promote sleep and relaxation. Known as the “sleepy cannabinoid”, CBN naturally evolves from THC as it degrades or ages over time. Although it originates from THC, CBN is a separate cannabinoid and doesn’t have the psychoactive effects commonly associated with THC. For those interested in trying CBN, True PM makes the list of the best CBN oil products! All of our oils have extensive third-party lab testing and have received high marks from users of this product.
Autoimmune Diseases such as: Lupus, Psoriasis, Type 1 Diabetes, Rheumatoid Arthritis, Inflammatory Bowel Disease, etc. have shown to be linked to stress. For example, in this study citing a higher incidence of autoimmune diseases among people who were previously diagnosed with stress-related disorders. Another paper publishes:
“Physical and psychological stress has been implicated in the development of autoimmune disease, since numerous animal and human studies demonstrated the effect of sundry stressors on immune function. Moreover, many retrospective studies found that a high proportion (up to 80%) of patients reported uncommon emotional stress before disease onset.
It is presumed that the stress-triggered neuroendocrine hormones lead to immune dysregulation, which ultimately results in autoimmune disease, by altering or amplifying cytokine [inflammatory response] production. The treatment of autoimmune disease should thus include stress management and behavioral intervention to prevent stress-related immune imbalance. “
Because of CBD’s ability to combat stress levels (see previous blog post), it provides as a preventative measure and potential therapy for Autoimmune Disorders as a stress management tool.
**These statements have not been evaluated by the food and drug administration (FDA). These products are not intended to diagnose, treat, cure or prevent any disease. The information is not medical advice, and should not be treated as such.
Modern-day science continues to show the link between Stress & Disease. Stress can be defined as any experience that causes tension, whether that be physical, psychological, or emotional- and especially if it sets off the “fight or flight” response – during which the adrenal gland releases adrenaline, leading to rapid pulse and breathing, and increased blood pressure).
“Chronic stress result [in] failures of homeostasis, [and] thus lead to various diseases such as atherosclerosis, non-alcoholic fatty liver disease (NAFLD) and depression. However, while 75%–90% of human diseases is related to the activation of stress system, the common pathways between stress exposure and pathophysiological processes underlying disease is still debatable.
Chronic inflammation is an essential component of chronic diseases. Additionally, accumulating evidence suggested that excessive inflammation plays critical roles in the pathophysiology of the stress-related diseases, yet the basis for this connection is not fully understood.” this paper publishes.
In previous blog posts, we have spoken widely about CBD’s potential in regulating inflammation and returning the body to homeostasis. We have even shown how CBD acts in a similar way as antidepressants as it works on the serotonin (5HT)1a receptor. Serotonin deficiency is associated with depression and other psychiatric disorders, and it is likely that the effects CBD has on mood and anxiety are related to this interaction.
It is suggested that CBD could be helpful in the treatment of anxiety and stress by many clinical trials and organizations such as this report by the WHO. Note the many benefits attributed to CBD oil—everything from curing insomnia and improving glaucoma, to reducing inflammation and lessening ANXIETY.
CBD has a broad pharmacological profile, including interactions with several receptors known to regulate fear and anxiety-related behaviors, specifically the CB1 receptor, the serotonin 5-HT1A receptor, and the transient receptor potential (TRP) vanilloid type 1 (TRPV1)receptor.
Thus, maintaining the balance between CB1 receptors and TRPV1 channel activation is crucial for regulating anxiety.