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CBD Benefits: Alcohol Consumption, Hangovers, and the Microbiota Gut-Brain Axis

Recently I stumbled upon some research that I just had to share. If you are anything like me and like to treat yourself to an alcoholic beverage every now and then (or more than every now and then) and detest that nasty hangover, then this one’s for you…

Based on this research, I now vow to always consume Cannabinoids alongside my alcohol consumption to help mitigate negative effects.

We all are somewhat aware that alcohol is essentially poison, but let’s get into what it really does so we can understand how to combat its negative effects…

Alcohol has been shown to cause damage to the frontal and temporal lobes of the brain, in particular by inducing neuroinflammatory mediators and/or oxidative stress. These brain regions are known to be associated with problem solving, attention, information processing, learning, and memory.

Since CBD has neuroprotective effects that prevent oxidative damage, it has been considered for the treatment of cognitive impairments caused by alcohol. These effects of CBD have been hypothesized to be mediated by the 5HT1A (serotonin), or CB2 receptors. 

These exciting results have been reported to support the potential therapeutic benefits of CBD for Alcohol Use Disorder, particularly in the areas of neurodegeneration, hepatotoxicity (chemical-driven liver damage), and  cognition.  Additionally, CBD can have a therapeutic effect in alcoholic liver diseases characterized by inflammation, oxidative stress, and steatosis (the abnormal retention of fat within a cell or organ).

There are several proposed mechanisms through which cannabinoids (and CBD in particular) may confer beneficial effects in the context of Alcohol Use Disorder (AUD). First, CBD may directly impact specific brain mechanisms underlying AUD to influence alcohol consumption and the clinical features of AUD.

Second, CBD may influence AUD symptoms through its actions across the digestive, immune, and central nervous systems, collectively known as the microbiota-gut-brain axis (MGBA). These MGBA disruptions have been associated with AUD symptoms such as craving and impaired cognitive control.

Furthermore, Preclinical data suggest that cannabinoids may confer beneficial effects on the gastrointestinal and immune system. These findings include reducing intestinal permeability, regulating gut bacteria, and reducing inflammation. Thus, cannabinoids may exert AUD harm-reduction effects, at least in part, through their beneficial actions across the MGBA.

Not to mention the effects alcohol has on dehydration. Electrolytes are what our bodies need to absorb water and remain hydrated. When people drink alcohol or caffeine, or exercise, not only do they become more dehydrated, but any water consumed after is not as effective due to a low balance of electrolytes.  Insufficient electrolyte replenishment is a leading cause of why over 75 percent of people are chronically dehydrated.

With cannabis now legal in several U.S. states and industrialized hemp production legal nationwide, consumer curiosity in alternative forms of stress-release and relaxation is piqued. Whether it is tetrahydrocannabinol (THC), CBD, or other botanicals with purported relaxation benefits, consumers are interested in trying drinks that support their desire to slow down, market research firms say.

I hope you have learned from our research, like we have greatly. If you are one of these people looking to try alternative forms of stress-release, or just something to help balance out the negative effects of booze when you do choose to consume, take a look at our products.

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Written by: Rylee Josipovich, Founder of Golden Bee Hemp & Robin H. McDonald, RPh, Research & Product Development Specialist for Natural Oils Inc.

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006 CBN & CBD for better Sleep with True PM with Robin, Research & Product Development Specialist

SPOTIFY at: https://open.spotify.com/show/1D1wNd0ew0imsez3tR3DMR
APPLE PODCASTS at: https://podcasts.apple.com/us/podcast/lets-talk-about-cbd/id1639848427

If you are ready to feel well rested and relaxed, then this is the podcast for you!

Exploring CBN as the “Mother” or “Sleepy” Cannabinoid, we discuss how these natural substances can help calm the body and the mind and help us drift off peacefully into dreamland!

We expel myths about CBD “being addictive,” and explore how these natural supplements can help the body in many ways to bring the body back to balance & homeostasis!

Hormones, Menopause, Melatonin Production, Mood, Seasonal Depression or “SADD” are also discussed in relation to CBD/CBN and as benefits from our products!

Listen in to find out how CBD can help you navigate Stress, Calm, Focus, Anxiety, Mood & more!

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Article Robin was referencing:

“Therapeutic properties of multi-cannabinoid treatment strategies for Alzheimer’s disease

Frontiers in Neuroscience; Lausanne (Sep 2, 2022). DOI:10.3389/fnins.2022.962922”Coles, MadilynSteiner-Lim, Genevieve ZKarl,is  Tim.

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FAQ: How Could CBD Help with PTSD?

 CBD molecules interact with the CB1 and CB2 receptors in the CNS, or the central nervous system and in the peripheral nervous system.

Interactions with these receptors prompt the release of serotonin. Medical research has shown that depressed persons exhibit lowered serotonin levels and therefore, it’s no secret that low serotonin leads to anxiety.

Treatment with CBD may also decrease the intensity and impact of  symptoms commonly associated with PTSD, including chronic anxiety in stressful environments.  Exposure to stress can trigger anxiety in PTSD patients and remind them of traumatic experiences. By reducing induced anxiety, CBD may help to regulate the negative effects associated with PTSD.

(The above is not medical advice.)

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FAQ: What is CBN & how can it help me Relax?

“Cannabiniol was the first Cannabinoid isolated from the Cannabis plant. The conversion process from THC to CBN can occur spontaneously in both Cannabis extracts and raw plant materials. CBN is a stable compound. It has a low affinity for the CB1 and CB2 cannabinoid receptors, but it is slightly higher for CB2. It is also an antagonist of the TPRM8 channels and a potent agonist of TRPA1. It has been described as a weak psychoactive compound. Studies have indicated the antibiotic, sedative, anti-inflammatory, and anticonvulsant effects of CBN.” Cannabis sativa L. as a Natural Drug Meeting the Criteria of a Multitarget Approach to Treatment International Journal of Molecular Sciences; Basel Vol. 22, Iss. 2,  (2021)

True PM, which is high in CBN (cannabiniol), is gaining popularity as a natural alternative to help promote sleep and relaxation. Known as the “sleepy cannabinoid”, CBN naturally evolves from THC as it degrades or ages over time. Although it originates from THC, CBN is a separate cannabinoid and doesn’t have the psychoactive effects commonly associated with THC. For those interested in trying CBN, True PM makes the list of the best CBN oil products! All of our oils have extensive third-party lab testing and have received high marks from users of this product.

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FAQ: What does the World Health Organization (WHO) say about CBD?

The following is page 18/27 of The World Health Organization’s report on CBD’s potential benefits:

https://www.who.int/medicines/access/controlled-substances/5.2_CBD.pdf

In terms of safety, the WHO reports:

“In humans, CBD exhibits no effects indicative of any abuse or dependence potential.”

“To date, there is no evidence of recreational use of CBD or any public health related problems associated with the use of pure CBD.”

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FAQ: What is the Relationship Between CBD & Autoimmune disorders?

Autoimmune Diseases such as: Lupus, Psoriasis, Type 1 Diabetes, Rheumatoid Arthritis, Inflammatory Bowel Disease, etc. have shown to be linked to stress. For example, in this study citing a higher incidence of autoimmune diseases among people who were previously diagnosed with stress-related disorders. Another paper publishes:

Physical and psychological stress has been implicated in the development of autoimmune disease, since numerous animal and human studies demonstrated the effect of sundry stressors on immune function. Moreover, many retrospective studies found that a high proportion (up to 80%) of patients reported uncommon emotional stress before disease onset.

It is presumed that the stress-triggered neuroendocrine hormones lead to immune dysregulation, which ultimately results in autoimmune disease, by altering or amplifying cytokine [inflammatory response] production. The treatment of autoimmune disease should thus include stress management and behavioral intervention to prevent stress-related immune imbalance. “

Because of CBD’s ability to combat stress levels (see previous blog post), it provides as a preventative measure and potential therapy for Autoimmune Disorders as a stress management tool.

**These statements have not been evaluated by the food and drug administration (FDA). These products are not intended to diagnose, treat, cure or prevent any disease. The information is not medical advice, and should not be treated as such. 

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FAQ: How can CBD help my Stress Levels?

Modern-day science continues to show the link between Stress & Disease. Stress can be defined as any experience that causes tension, whether that be physical, psychological, or emotional- and especially if it sets off the “fight or flight” response – during which the adrenal gland releases adrenaline, leading to rapid pulse and breathing, and increased blood pressure).

“Chronic stress result [in] failures of homeostasis, [and] thus lead to various diseases such as atherosclerosis, non-alcoholic fatty liver disease (NAFLD) and depression. However, while 75%–90% of human diseases is related to the activation of stress system, the common pathways between stress exposure and pathophysiological processes underlying disease is still debatable.

Chronic inflammation is an essential component of chronic diseases. Additionally, accumulating evidence suggested that excessive inflammation plays critical roles in the pathophysiology of the stress-related diseases, yet the basis for this connection is not fully understood.” this paper publishes.

In previous blog posts, we have spoken widely about CBD’s potential in regulating inflammation and returning the body to homeostasis. We have even shown how CBD acts in a similar way as antidepressants as it works on the serotonin (5HT)1a receptor. Serotonin deficiency is associated with depression and other psychiatric disorders, and it is likely that the effects CBD has on mood and anxiety are related to this interaction.

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FAQ: Could CBD help my Anxiety?

It is suggested that CBD could be helpful in the treatment of anxiety and stress by many clinical trials and organizations such as this report by the WHO. Note the many benefits attributed to CBD oil—everything from curing insomnia and improving glaucoma, to reducing inflammation and lessening ANXIETY.

CBD has a broad pharmacological profile, including interactions with several receptors known to regulate fear and anxiety-related behaviors, specifically the CB1 receptor, the serotonin 5-HT1A receptor, and the transient receptor potential (TRP) vanilloid type 1 (TRPV1)receptor.

Thus, maintaining the balance between CB1 receptors and TRPV1 channel activation is crucial for regulating anxiety. 

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