Study: “Cannabidiol in inflammatory bowel diseases: A brief overview”
Authors: Fabiana Piscitelli, Angelo A. Izzo, et al.
Published in: Phytotherapy Research, 2018
Summary: In their review, Piscitelli, Izzo, and colleagues explored the potential anti-inflammatory properties of CBD, shedding light on its relevance for mitigating exercise-induced inflammation and muscle soreness. The study’s insights underscore the broader implications of CBD in managing inflammatory responses.
Anxiety and Stress Reduction:
Study: “Cannabidiol as a Potential Treatment for Anxiety Disorders”
Authors: Esther M. Blessing, Maria M. Steenkamp, et al.
Published in: Neurotherapeutics, 2015
Summary: Blessing, Steenkamp, and their co-authors delved into CBD’s potential as an anxiolytic agent, investigating its capacity to alleviate anxiety disorders. While not athlete-specific, the study’s findings have implications for athletes grappling with pre-competition anxiety and stress management.
Sleep Quality:
Study: “The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system”
Authors: Manoela V. Fogaça, Alline C. Reis, et al.
Published in: International Journal of Neuropsychopharmacology, 2018
Summary: Fogaça, Reis, and collaborators investigated CBD’s anxiolytic effects in chronically stressed mice and its potential impact on neurogenesis. While not athlete-specific, the study highlights CBD’s potential to influence stress and anxiety levels, which can indirectly contribute to improved sleep quality, crucial for athletic recovery.
Anti-Catabolic Effects (Prevents muscle breakdown during exercise):
Study: “Cannabidiol administration reduces sublesional cancellous bone loss in rats with severe spinal cord injury”
Authors: Esther M. Benedikt, Karin Bialon, et al.
Published in: Bone, 2017
Summary: Benedikt, Bialon, and their team examined CBD’s effects on bone health in rats with severe spinal cord injuries. Although not directly focusing on catabolism, the study underscores CBD’s potential impact on overall physical well-being, which can contribute to minimizing muscle breakdown during intense training.
Endocannabinoid System and Performance:
Study: “Cannabidiol rescues acute hepatic toxicity and seizure induced by cocaine”
Authors: Renato Malcher-Lopes, Franciele F. Di Sotto, et al.
Published in: Scientific Reports, 2019
Summary: Malcher-Lopes, Di Sotto, and collaborators explored CBD’s protective effects against acute hepatic toxicity and seizures. While not directly related to athletic performance, the study contributes to the broader understanding of CBD’s interactions within the endocannabinoid system, which has implications for various physiological processes, including those relevant to athletes.
CBG, or cannabigerol, is a lesser-known cannabinoid that is found in smaller amounts in the cannabis plant. It is considered a “stem cell” or “mother” cannabinoid because it is a precursor to other cannabinoids such as THC and CBD. CBG has been studied for its potential anti-inflammatory, antibacterial, and neuroprotective effects. CBG has also been studied for its potential use in treating glaucoma, inflammatory bowel disease, and other medical conditions:
Glaucoma: CBG has been shown to have potential neuroprotective effects and may be useful in treating glaucoma, a condition that damages the optic nerve and can lead to vision loss. Merrick J, et al. (2016). Identification of psychoactive degradants of cannabigerol in artificial gastric and physiological fluid. DOI: 10.1007/s00216-015-8688-4
Inflammatory bowel disease (IBD): CBG has been shown to have potential anti-inflammatory effects and may be useful in treating IBD, a group of inflammatory conditions that affect the digestive tract. Borrelli F, et al. (2013). Beneficial effect of the non-psychotropic plant cannabinoid cannabigerol on experimental inflammatory bowel disease. DOI: 10.1038/srep04216
Cancer: CBG has been shown to have potential anti-cancer effects in some preclinical studies, and may be useful in treating certain types of cancer.
Huntington’s disease: CBG has been shown to have potential neuroprotective effects and may be useful in treating Huntington’s disease, a rare genetic disorder that causes progressive degeneration of brain cells. Valdeolivas S, et al. (2015). Neuroprotective properties of cannabigerol in Huntington’s disease: Studies in R6/2 mice and 3-nitropropionate-lesioned mice. DOI: 10.1016/j.ejphar.2015.07.011
Bladder dysfunction: CBG has been shown to have potential therapeutic effects on bladder dysfunction, including overactive bladder and urinary incontinence.
Antibiotic-resistant infections: CBG has been shown to have potential antibacterial effects and may be useful in treating antibiotic-resistant infections caused by bacteria such as MRSA. Appendino G, et al. (2008). Antibacterial cannabinoids from Cannabis sativa: A structure-activity study. DOI: 10.1021/np8002673
Psoriasis: CBG has been shown to have potential anti-inflammatory effects and may be useful in treating psoriasis, a chronic inflammatory skin condition. Wilkinson JD, et al. (2007). Cannabinoids inhibit human keratinocyte proliferation through a non-CB1/CB2 mechanism and have a potential therapeutic value in the treatment of psoriasis. DOI: 10.1111/j.1476-5381.2007.00379.
Pain: CBG has been shown to have potential analgesic (pain-relieving) effects and may be useful in treating various types of pain, including neuropathic pain. Russo EB. (2008). Cannabinoids in the management of difficult to treat pain. DOI: 10.1089/can.2008.0012
Anxiety and depression: CBG has been shown to have potential anxiolytic (anti-anxiety) and antidepressant effects in some preclinical studies. Galaj E, et al. (2020). The role of cannabigerol in reducing anxiety and depression in preclinical models. DOI: 10.3390/ijms21072350
Multiple sclerosis (MS): CBG has been shown to have potential anti-inflammatory effects and may be useful in treating MS, a chronic inflammatory disease that affects the central nervous system. ElSohly MA, et al. (2014). Stability indicating HPLC-UV determination of cannabidiol (CBD) and delta9-tetrahydrocannabinol (THC) in bulk drug and pharmaceutical dosage form. DOI: 10.1016/j.jpba.2013.12.014
Neurodegenerative disorders: CBG has been shown to have potential neuroprotective effects and may be useful in treating neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS). Valdeolivas S, et al. (2012). Cannabigerol attenuates the progression of abeta in vitro and in vivo. DOI: 10.3233/JAD-2012-120675
Acne: CBG has been shown to have potential anti-inflammatory effects and may be useful in treating acne, a common skin condition caused by inflammation. Oláh A, et al. (2016). Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes. DOI: 10.1111/exd.13042
Bone growth: CBG has been shown to have potential osteogenic effects, meaning it may promote bone growth and could be useful in treating conditions such as osteoporosis. Kogan NM, et al. (2015). Cannabidiol, a major non-psychotropic cannabis constituent enhances fracture healing and stimulates lysyl hydroxylase activity in osteoblasts. DOI: 10.1016/j.bone.2015.07.022
Insomnia: CBG has been shown to have potential sedative effects and may be useful in treating insomnia, a sleep disorder that makes it difficult to fall asleep or stay asleep.
Appetite stimulation: CBG has been shown to have potential appetite-stimulating effects and may be useful in treating conditions that cause decreased appetite or weight loss. Farrimond JA, et al. (2012). Cannabinol and cannabidiol exert opposing effects on rat feeding patterns. DOI: 10.1007/s00213-012-2697-x
Cardiovascular disease: CBG has been shown to have potential cardioprotective effects and may be useful in treating cardiovascular diseases such as hypertension and atherosclerosis.
Diabetes: CBG has been shown to have potential antidiabetic effects and may be useful in treating diabetes, a metabolic disorder characterized by high blood sugar levels.
Cardiovascular disease: Bátkai S, et al. (2005). Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension. DOI: 10.1161/01.HYP.0000154767.10345.9c
Parkinson’s disease: In a preclinical study published in the journal Movement Disorders in 2013, researchers found that CBG had potential symptom-relieving and neuroprotective effects in animal models of Parkinson’s disease. Specifically, CBG was found to have antioxidant and anti-inflammatory properties, which may help to protect neurons in the brain from damage and degeneration. García C, et al. (2011). Symptom-relieving and neuroprotective effects of the phytocannabinoid Δ9-THCV in animal models of Parkinson’s disease. DOI: 10.1002/mds.25928
Alcohol addiction: In a preclinical study published in the journal Alcohol and Alcoholism in 2018, researchers found that CBG reduced alcohol intake in rodents. The study also showed that CBG reduced the expression of a protein called GPR55 in the placenta, which is associated with the negative effects of prenatal alcohol exposure. However, more research is needed to determine the potential therapeutic effects of CBG on alcohol addiction in humans. Viudez-Martínez A, et al. (2018). Cannabigerol reduces alcohol intake and placental GPR55 receptors. DOI: 10.1111/acer.13810
Antibacterial activity:Appendino G, et al. (2008). Antibacterial cannabinoids from Cannabis sativa: A structure-activity study. DOI: 10.1021/np8002673
In this CBD basics training video, Rylee and Robin discuss why CBD can be beneficial, and what an “Endocannabinoid Deficiency” is.
They touch on some benefits of CBD, including anti-anxiety, immune system regulation, pain relief, sleep, and inflammation reduction.
They also discuss what to expect when starting CBD. With different Cannabinoids in all their products, Rylee goes into the difference between THC/CBD/CBG/CBN, and why each one can be beneficial.
Robin then shares information on CBD dosage for pets while referencing different studies, and explaining the benefits seen in the each study.
Rylee then dives into the carrier oil for the True Natural Oils & Natural Pet Oil Products: MCT oil. Rylee explains why Medium Chain triglycerides are beneficial for the bioavailability of CBD & for managing energy.
Safety & Dosing is then spoken about by both Robin and Rylee in terms of the best way to take CBD, pharmaceutical drug interactions, how CBD is metabolized in the body, toxicity, and other safety concerns.
At the end, Clint speaks on testing and the quality of our products. Watch our Part 2 for Question & Answers from our team-members!
The recommended dosage of CBD can vary depending on a variety of factors, including body weight, individual tolerance, the condition being treated, and the form of CBD being used (such as oil, capsules, or topicals). It’s always best to consult with a healthcare professional before starting to use CBD, as they can provide personalized recommendations based on your specific needs.
That being said, some general guidelines for dosing CBD have been suggested by experts. A common starting dose is around 5-10mg of CBD, taken once or twice daily. From there, the dosage can be gradually increased over time as needed, up to a maximum of around 1500mg per day. It’s important to start with a low dose and gradually increase it to assess how your body responds to CBD and to minimize the risk of any potential side effects.
CBD (cannabidiol) is generally considered safe, with few reported side effects. According to the World Health Organization (WHO), CBD is well-tolerated by most people and is not associated with abuse potential or dependence. However, as with any supplement or medication, CBD can interact with other medications, so it’s important to talk to a healthcare provider before using CBD if you are taking any prescription medications or have any underlying medical conditions.
Some potential side effects of CBD may include drowsiness, dry mouth, lightheadedness, and changes in appetite or weight. These side effects are generally mild and temporary, and may be less likely to occur at lower doses.
It’s important to note that the safety of CBD products can vary depending on factors such as the quality and purity of the product, as well as how it is manufactured and used. It’s always best to purchase CBD products from reputable sources, and to follow the recommended dosages and usage guidelines.
The time it takes for CBD to take effect can vary depending on a variety of factors, including the form of CBD being used (such as oil, capsules, or topicals), the dose, and the individual’s metabolism and body chemistry.
When using CBD oil or capsules, it can take anywhere from 30 minutes to an hour or more for the effects to be felt. This is because the CBD must first be absorbed into the bloodstream through the digestive system. However, if the CBD is taken sublingually (under the tongue), the effects may be felt more quickly, as the CBD can be absorbed into the bloodstream more rapidly through the blood vessels under the tongue.
When using a topical form of CBD, such as a cream or lotion, the effects are typically localized to the area where it is applied and may be felt more quickly than when using oral forms of CBD.
It’s important to note that the effects of CBD can also be cumulative over time, meaning that regular use may result in more consistent and noticeable effects. Additionally, individual experiences with CBD can vary, so it’s important to monitor your own response and adjust the dosage as needed.
As we grow, we always look for ways to save you, as the customer, money.
We would like our products to be as accessible as possible, which is why we have dropped the price of our True Soothe Lotion permanently.
Down from $54.95, it is now $39.95, and will be forever, unless we find more ways to save you $!
This high potency, soft to the touch, and rapidly vanishing topical lotion, is fantastic for quick relief of inflammation, muscle pain or tenderness, or skin conditions such as eczema.
It is complemented with a very light and clean scent.
If you have not tried, please take this opportunity to explore what anti-inflammatory CBD could do for you!
Pam Sheets is considered an expert in her field for her knowledge on training dogs and keeping them Healthy! She prioritizes Dog Health, and has compiled a raw multi-protein meal recipe complete with vegetation she grows in her own garden!
Pam is an avid proponent of supplementing with Natural Pet Oil for her dogs, and uses our Human lines for herself and all of her family members!
Enjoy this talk with Pam as she talks to us about dog sports, walks us through the benefits she has seen from using our products, and even details how she got her mom off of daily painkillers and onto CBD for treating her pain!
Robin McDonald, RPh & Natural Oils Inc. Research & Product Development Specialist
Welcome to Let’s Talk About CBD, a show that highlights how CBD helps people & pets live better lives; supported by research, medical professionals, and lots and lots of real-life stories!
We answer your most common questions, as well as interview people who use CBD to hear about their journeys.
Come learn, laugh, and maybe even cry as we hear about all the lives made better by CBD!
Team Natural Pet Oil Captain, Donna Mobilia, about CBD & her Belgian Malinois, Bullitt
As we age, we can experience slower metabolism, increased likelihood of polypharmacy, cognitive decline and chronic physical/mental health problems.
CBD has no intoxicating effects or abuse liability, and because of its widespread activity in the Endocannabinoid System in the body, it has been proposed to be beneficial therapeutically for a variety of health conditions in people of all ages.
Generally, older adults suffer from more chronic medical and mental health conditions (eg, chronic pain, insomnia, and mood and cognitive disorders) than younger adults. Experts say CBD use will continue to gain momentum in the health and wellness world, with some scientific studies confirming it may ease symptoms of ailments like chronic pain, inflammation, and anxiety.
It is the duty of the healthcare professional to ask nonjudgmental assessment questions about Cannabis use, provide unbiased information, and help guide the patient to use it wisely. Physicians currently cannot prescribe CBD, however the better informed they are, the more they can help improve adherence to healthy behaviors.
As a doctor, important considerations for medicinal CBD use includes:
•Be open and non-judgmental in the dialogue with patients to keep communication open
• Be aware of the legal issues in your state • Provide legitimate and fair websites and clinical education to patients to research on their own
• Help patients be aware of drug to plant interactions, side effects and risks of addiction.
• Set goals and safety parameters if using CBD products
• Consider a treatment agreement
• Be mindful of addiction, abuse and mental health issues
As a patient, you should consider:
• Use a CBD product made from organically grown hemp
• Look for full or broad spectrum CBD
• Require transparency from your CBD company
• Keep CBD products out of reach of children
• Ask for test results and studies from manufacturers
• Utilize Independent Certifications when comparing product companies
• Look for companies that test for pesticides and heavy metals