CBD molecules interact with the CB1 and CB2 receptors in the CNS, or the central nervous system and in the peripheral nervous system.
Interactions with these receptors prompt the release of serotonin. Medical research has shown that depressed persons exhibit lowered serotonin levels and therefore, it’s no secret that low serotonin leads to anxiety.
Treatment with CBD may also decrease the intensity and impact of symptoms commonly associated with PTSD, including chronic anxiety in stressful environments. Exposure to stress can trigger anxiety in PTSD patients and remind them of traumatic experiences. By reducing induced anxiety, CBD may help to regulate the negative effects associated with PTSD.
Here, we report the case of a 20-year-old man with severe social anxiety disorder, major depressive disorder, insomnia and attenuated psychotic symptoms despite ongoing treatment with cognitive behavioral therapy and mirtazapine who was treated with adjunctive cannabidiol (CBD) in doses between 200 and 800 mg/day for 6 months.
During treatment with CBD, he experienced subjective benefits to his anxiety, depression and positive symptoms during treatment that were confirmed by clinicians and by standardized research instruments.
Findings from this case study add to existing evidence in support of the safety of CBD and suggest that it may be useful for young people with treatment refractory anxiety and for attenuated psychotic symptoms.
Treatment of social anxiety disorder and attenuated psychotic symptoms with cannabidiol Berger, Maximus; Li, Emily; Amminger, Günter Paul. BMJ Case Reports; London Vol. 13, Iss. 10, (Oct 2020). DOI:10.1136/bcr-2020-235307
“I DON’T REALLY FEEL ANYTHING DIFFERENT.” This is heard so many times among CBD users who are concerned about their dose being low at first. More than likely, too low! And then, consequently, they don’t follow up with what their “sweet spot dose” of CBD truly is. Please read to discover the true dose your body is prepared to receive:
True Natural Oils offers different CBD oils with various strengths. Hence, one drop of full-spectrum CBD oil with 750 mg of CBD concentration is not the same as one drop of full-spectrum CBD oil with 3000mg of CBD. When choosing the best dosage for you, there are some things to be considered.
For example, the CBD concentration in each CBD oil bottle, the user’s body weight and the condition that is to be treated. Even after determining these factors, there is still no ‘one-size-fits-all’ type of dosage. One option is to consume 1-6mg of CBD for every 10 pounds of body weight or to start. You may also consider a trial period where you would determine the most suitable dosage for you.
In comparison, the only FDA approved CBD – Epidiolex – is dosed as follows. Median dose is 12.5 mg/kg given twice daily. Maximum dose is 25 mg/kg given daily. For the median dose, if you weigh 150 pounds then 852 mg of CBD given twice daily would be FDA recommended. Now that is not a feasible dosage for general relief of pain or anxiety. It would require many ml’s of the oils to achieve this dosage.
What I would like to point out is that the FDA deems that dosage as a safe treatment dosage. Always consult with a doctor or contact the provider to get more information and some tips. You could experience tiredness, diarrhea or lightheadedness if your dosage is off. In some cases, there might be a change in weight as well. *This is not medical advice.*
The Month of February is all about Hearts. It is designated as Heart Health Month in the US, a time when all people can focus on their cardiovascular health.
Cardiovascular diseases (CVDs) are the leading cause of mortality worldwide. They have a set of characteristic molecular components, such as a proinflammatory profile present in heart failure (HF), diabetic cardiomyopathy, and autoimmune myocarditis.
All of these molecular components associated with diverse CVDs can be modulated with Cannabinoid administration. Of particular interest of the Cannabinoids present in Cannabis, which is also produced within our bodies, has been CBD.
CBD is a potent anti-inflammatory andreduces the production of reactive oxygen and nitrogen species, thus resulting in reduced tissue injury. Such effects can be taken advantage of in varied diseases, such as cardiovascular and neurodegenerative diseases, cancer, pain, obesity, and metabolic syndrome.
Hypertension, or high blood pressure, is often called the ‘silent killer’ because most people who have it don’t have any symptoms. This can be a scary notion if we let it be, but we can also choose to take care of our bodies by making healthy choices to maintain our overall wellness.
A recent 2017 study on cardiac parameters in healthy males showed that subjects who had taken CBD, as opposed to a placebo, experienced lower blood pressure when exposed to stress.
In a 2009 study on rats, they were subjected to stressful situations, which in turn increased their heart rate and blood pressure. When the rats were then given a dose of CBD, their blood pressure and heart rate lowered.
It is proven high blood pressure can lead to stroke, heart attack, vision loss and kidney disease. However, we have now seen how CBD can be of great value as a cardioprotective agent due to its potent antioxidant and anti-inflammatory properties.
As advocates in the CBD industry, our team is pleased to see many clinical studies employing the use of CBD as potential treatments of such destructive diseases. We also know encourage our community to remember that CBD is not a cure-all, though it can help. A balanced diet, mindset, and lifestyle are just as important in maintaining a healthy body and a health heart.
Thank you for letting us share this information with you. As always, this is not Medical Advice. Consult your trusted health professional, especially if you are on any prescribed medication.
Alcohol has been shown to cause damage to the frontal and temporal lobes of the brain, in particular by inducing neuroinflammatory mediators and/or oxidative stress.These brain regions are known to be associated with problem solving, attention, information processing, learning, and memory.
Since CBD has neuroprotective effects that prevent oxidative damage, it has been considered for the treatment of cognitive impairments caused by alcohol. These effects of CBD have been hypothesized to be mediated by the 5HT1A (serotonin), or CB2 receptors.
These exciting results have been reported to support the potential therapeutic benefits of CBD for Alcohol Use Disorder, particularly in the areas of neurodegeneration, hepatotoxicity (chemical-driven liver damage), and cognition. Additionally, CBD can have a therapeutic effect in alcoholic liver diseases characterized by inflammation, oxidative stress, and steatosis.
There are several proposed mechanisms through which cannabinoids (and CBD in particular) may confer beneficial effects in the context of Alcohol Use Disorder (AUD). First, CBD may directly impact specific brain mechanisms underlying AUD to influence alcohol consumption and the clinical features of AUD.
Second, CBD may influence AUD symptoms through its actions across the digestive, immune, and central nervous systems, collectively known as the microbiota-gut-brain axis (MGBA). These MGBA disruptions have been associated with AUD symptoms such as craving and impaired cognitive control.
Furthermore, Preclinical data suggest that cannabinoids may confer beneficial effects on the gastrointestinal and immune system. These findings include reducing intestinal permeability, regulating gut bacteria, and reducing inflammation. Thus, cannabinoids may exert AUD harm-reduction effects, at least in part, through their beneficial actions across the MGBA.
Not to mention the effects alcohol has on dehydration. Electrolytes are what our bodies need to absorb water and remain hydrated. When people drink alcohol or caffeine, or exercise, not only do they become more dehydrated, but any water consumed after is not as effective due to a low balance of electrolytes. Insufficient electrolyte replenishment is a leading cause of why over 75 percent of people are chronically dehydrated.
When it comes to CBD products, quality is EVERYTHING. In this rapidly growing industry there are many companies basically selling lessor quality oil slapped with a label claiming to be “high-quality CBD.”
In an industry saturated with imposters, it’s important to find companies you can trust and who actually sell a product that works. True Natural Oils is one of these companies.
Extraction method of Cannabinoids from the Cannabis plant is a critical step in the process that can make or break the availability of Cannabinoids in your product. Using the most advanced extraction equipment and technology, each batch of True Natural CBD oil is CO2 extracted at low temperatures. These low temperatures ensure that the extraction process is safe and gentle, preserving all the beneficial cannabinoids, terpenes, and flavonoids that are naturally present in high-quality CBD oil.
Full-spectrum extraction methods mean that you, the consumer, are presented with a CBD oil that stands up to its claims. Full-spectrum CBD oils are known to contain other cannabinoids, terpenes, essential oils, and amino acids that work in harmony to create beneficial effects. This is known as the entourage effect.
Each batch is carefully monitored and tested throughout the entire extraction process, then sent to a third-party lab for further testing. True Natural Oils takes pride not only in the quality of our product, but in being completely transparent and open to anyone who wants to look at our current third-party test results posted on our website.