“Cannabinoids and Blood–Brain Barrier (BBB): The BBB works as an effective border between the Central Nervous System, and systemic circulation & microglia represents the main line of defense of the brain. When neuroinflammation occurs, the BBB protective function can be reduced by an inflammatory reaction from an immune-related cells involvement.
The BBB is prone to the consequences due to chronic systemic inflammation as it leads to brain inflammation and consequently can impair its integrity.
In this context, interest has grown about the cannabinoids as potential anti-inflammatory drugs. These findings suggest that CBD could be part of a new strategic approach useful to treat inflammatory diseases of [Central Nervous System] indicating that CBD might be useful for the positive modulation of the BBB as a future treatment in ischemic stroke.”
Cannabinoids, Blood–Brain Barrier, and Brain Disposition” Calapai, Fabrizio; Cardia, Luigi; Sorbara, Emanuela Elisa; Navarra, Michele; Gangemi, Sebastiano; et al. Pharmaceutics; Basel Vol. 12, Iss. 3, (2020): 265. DOI:10.3390/pharmaceutics12030265
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