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Traumatic Brain Injuries

Traumatic brain injury affects a high number of young adults and their hospitalization is still a significant public challenge. During neuronal damage a complex series of mechanisms becomes activated. Energy failure leads to calcium overload, depolarization of neurons and release of neurotransmitters with consecutive excitotoxicity, induced through overstimulation from excitatory receptors like NMDA receptor.

Injured neuronal tissue releases pro-inflammatory cytokines leading to migration of inflammatory cells to the damaged site and inflammation.  Cannabinoids (CBD) positively affect cellular and molecular processes during ischemic or traumatic brain injury and were shown to be protective mostly via microglial cells.

The number of damaged neurons was significantly reduced after treatment with endocannabinoids, like N-arachidonoyl dopamine, (2-AG) or PEA associated with altered microglial cell number.  2-AG was shown to induce protection after neuronal lesion and to reduce the amount of tumor necrosis factor α released from LPS activated microglial cells.

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What CBD oil is good for

If you follow cannabis news, you’re bound to have learned about a slew of conditions CBD oil is good for, including chronic pain and anxiety. But there are other uses that you may not have heard of yet.

Quitting smoking is one of the most difficult tasks for someone with a habit. Now anecdotal evidence shows that CBD can help not only with the depression and anxiety associated with quitting, but if you use a CBD pen in lieu of a cigarette or nicotine vape pen, the hand to mouth motion helps with that part of the addiction. Many people trying not to smoke find that they don’t know what to do with their hands during times when they crave a cigarette or e-cig, so a CBD vape pen is a perfect solution on many levels.

Did you know that CBD may have an effect on high blood pressure? Though you are always advised to talk to your doctor about treatments and to not stop any other treatment plans, adding CBD oil to your list of supplements couldn’t hurt. It is an innocuous component of the cannabis plant and has no psychoactive properties whatsoever when under the 0.3 percent THC mark. The fact that CBD also combats anxiety means that you shouldn’t be nervous to add it to your daily regime.

Talk to a medical consultant at True Natural Oils about dosages, milligrams and delivery systems. 

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Robin’s wRite Ups

Summertime and Sunshine and Sunburn! SuS

Summertime and Sunshine and Sunburn!

Welcome back to everyone!  I trust you all are getting out and enjoying your summer as much as the pandemic is allowing!   Gathering with friends, picnicking in a park or simply being in the fresh air in the backyard for the afternoon all can be so delightful. 

As beaches and pools re-open for exercise I see many people extending their time out in the warm sun.  Many of us are diligent in spraying on our trusty sunscreen.  Unfortunately, some are in a rush to get out of the house to begin enjoying the day!  If perhaps the latter is you and you are suffering with a painful sunburn, stay tuned!  I have good information for you!

As I have talked about in the past, CBD has so many calming and nourishing properties for our skin.  Anything from muscular aches to topical burns to preventing wrinkles; CBD has may uses.  And, as this time of year, sunburn is at the top of skin related concerns. 

Our True Natural Oils products contain the plant’s natural full spectrum of cannabinoids, phytonutrients, terpenes and chlorophyll – a whole plant profile that gives the products powerful anti-inflammatory, antioxidant and antibacterial properties. These functional CBD lotions and oils are preferred by customers with problem or irritated skin, sunburn and minor aches and are good for skin conditions, scars, normal inflammation, redness and discomfort.

On a personal note, this 4th of July lent my husband and I to enjoy being out on the water with friends for the entire afternoon.  My husband, in the aforementioned paragraph, was in the “latter” group and neglected his sunscreen.  His face was painfully sunburnt.  I am thankful to report that applying a soothing layer of our True Fusion Oil to his face relaxed the pain, inflammation and took away the burning.  The next day he awoke without the tight, sunburned feeling.  Again, another wonderful application of our terrific product.  I am so pleased about all of the many benefits of CBD and I continue to be excited to share them with you.  

Until next time, please stay healthy and well, enjoy the summer and take good care!

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CBD is often used for anxious pets

The increased demand for wellness and self-care products during the coronavirus pandemic has made more people curious about trying CBD, even though it has yet to be approved by the Food and Drug Administration.

Separate from the actual virus, quarantine itself brings its own share of ills, such as anxiety, depression, sleeping problems, muscle pain from inactivity and, of course, crippling boredom. Although CBD is on its way to be clinically proven to reduce anxiety, reducing anxiety is a key selling point for CBD, so it makes sense that in a time of public uncertainty more people would be open to experimenting with it.

As many of us are home with our beloved pets, Animals also have an endocannabinoid system, CBD is often used for anxious pets. Many CBD product lines now include items specifically for animals; there are also CBD brands dedicated entirely to them, including Natural Pet Oils , which has separate product lines for dogs, cats and an array of pets.

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Potential Treatment For Heroin

CBD has been evaluated as a potential treatment for heroin craving by assessing its effects in heroin abusers. A small double-blind design was conducted in opioid-dependent individuals (no dependence on any other drug than heroin according to the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition) who, based on urine toxicology screening and the Clinical Opioid Withdrawal Scale, had been abstinent for at least 7 days.

As the preclinical animal study had evaluated CBD effects following the administration of a single dose of CBD for 3 consecutive days, the human study design for the pilot experiment also had a similar design. As such, individuals were randomized to 3 consecutive days of CBD or placebo treatment before participating in laboratory sessions.

The craving paradigm consisted of cue-induced craving test sessions where opioid-related and neutral video cues were presented at 1 h after a single CBD/placebo administration, 24 h after a single CBD/placebo administration, and 7 days following the final CBD/placebo administration.

The results showed that a single administration of CBD, in com-parison to placebo, attenuated subjective cue-induced craving measured after 1 h using the VAS craving scale.

The single administration of CBD even maintained a decrease of general craving 24 h later, assessed using a heroin-craving questionnaire. Furthermore, the effect of CBD in reducing craving persisted even 7 days after the last treatment. Interestingly, the effects of CBD were also evident on anxiety in which there was an effective reduction in VAS anxiety measures.

These preliminary pilot human study findings support the preclinical evidence and clinical studies that have evaluated anxiety, suggesting a potential therapeutic efficacy of CBD to reduce negative states in opioid-dependent individuals, which may, in turn, predict reduced craving and hence reduce the likelihood of relapse behavior.

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CBD Helps!

CBD continues to be a constant in helping people through this uncertain time. This is precisely why CBD stores should be considered essential: If hemp and CBD products can be sold in other businesses classified as critical, the government must recognize on some level that access to CBD is essential. Still others pointed to the inconsistencies between how marijuana and alcohol have been treated under quarantine in comparison to CBD. If liquor and marijuana are considered essential, why isn’t CBD?

Consumers rely on CBD for everyday wellness and there are dozens of stories from CBD consumers whose health and well-being deteriorate markedly when they do not have access to their daily CBD regimen.

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True Natural Oils is Striving to Move Forward in Development

True Natural Oils is Striving to Move Forward in Development

The well-known saying for those hawking baseball scorecards might be just as appropriate in the fledgling CBD category. With more and more players entering the marketplace and many predicting that the category is finally ready to explode in sales, retailers may need a scorecard to know who the players are in the marketplace.

According to Boulder, Colo.-based BDS Analytics and Market Research, the collective market for CBD sales, which includes cosmetics, health products, food and beverage, pet products, skin care, and pharmaceuticals, is expected to exceed $20 billion in the United States by 2024.

We at True Natural Oils still are waiting for the Food and Drug Administration & develop regulations related to CBD in food and dietary supplements. The FDA maintains that there is a lack of scientific information supporting the use of CBD in food, and also noted that the agency is continuing to explore pathways for various types of CBD products to be marketed.

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Daily Regimens

Increasingly, patients are asking about or have already begun to add CBD to their daily regimens. What evidence is there for the efficacy of CBD?

Small trials in humans have examined the use of high-dose CBD (typically 300 to 1,000 mg per day, taken orally) in social anxiety in a simulated public speaking model (Bergamaschi et al., 2011; Zuardi et al., 2017).

Eating disorders are another area of interest, as the endocannabinoid system is a key regulator of appetite, but have not been examined in clinical trials. Finally, the antidepressant potential of CBD (possibly due to 5HT1A agonism, similar to some antidepressant medications) has been explored in more clinical studies with impressive results in relieving anxiety.

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Let’s Figure Out A Way to Play Life Better

Let’s Figure Out A Way to Play Life Better

Psychiatric clinicians are often asked to treat patients with evidence-based methods, but the evidence to guide practice does not always reflect the reality that they confront every day.

Currently, many patients are using cannabinoids, particularly cannabidiol (CBD), to treat their own symptoms, ranging from insomnia to anxiety to depression. What doses of CBD should they be using? What route? How will CBD interact with other medications?

The mammalian endocannabinoid system includes the neurotransmitters anandamide (AEA) and 2-Arachidonoylglycerol (2-AG), their synthesizing and degrading enzymes, and their activity as partial and full agonists, respectively, at the Cannabinoid 1 and 2 (CB1, CB2) receptors. How this neurotransmitter system works as a retrograde signaling mechanism to fine tune other neurotransmitters, such as serotonin, norepinephrine, dopamine, and GABA. In clinical settings, finding the action of CBD on the endocannabinoid system will be an attempt to make rational choices about the role of exogenous cannabinoids in psychiatric practice.

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CBD for Mood, Antidepressants & Anxiety

CBD works by interacting with the body’s own regulatory system called the Endocannabinoid System (ECS).

The ECS plays an essential role in keeping the body functioning properly within a narrow range of operating conditions, and controls important functions like mood, memory, stress, sleep, behavior, appetite, pain, immune function and reproductive health. CBD can bind to these receptors in our bodies and activate the Endocannabinoid System, thereby regulating the same functions.

If this seems a bit too geeky all you need to remember is that CBD works a bit like social media- it acts everywhere and controls everything.

How does CBD oil ease anxiety?

As described above,  CBD works with the endocannabinoid system to produce some of the effects that people report, but CBD is also binding to other receptors in the brain like the serotonin (5HT)1a receptor. Serotonin deficiency is associated with depression and other psychiatric disorders, and it is likely that the effects CBD has on mood and anxiety are related to this interaction.

The ways CBD work in the brain are complicated and research is still lacking, but there is evidence to suggest that CBD might even work against depression and addictive disorders. The antidepressant potential, possibly due to 5HT1A agonism, has been explored in clinical studies with impressive results in relieving anxiety and boosting mood. 

Furthermore, in contrast to pharmaceutical antidepressants, CBD does not have addictive properties. You can start and stop using it at any time without side effects. 

We hope this has eased some of your worries about CBD, and can potentially help ease some of your worries in your everyday lifestyle with daily consumption. Please read on for more education or shop our lab-tested, Pharmacist- Formulated products now. 

Written by Robin, Research & Product Development Specialist. 

 

Not Medical advice. Not intended to treat, cure, prevent, or diagnose any disease