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CBD: Topical vs oral administration


“A common problem associated with ORAL transmucosal administration via the buccal route (in cheek or under tongue), is swallowing the dose due to the continuous secretion of saliva in the mouth. This contributes to decreased absorption of CBD in the body if not properly administered.  For optimal CBD delivery the buccal and sublingual gummies and Oils must remain in contact with oral mucosa for 60 – 90 seconds to allow for the absorption of the CBD. More specifically, the dosage form must not be washed away by saliva into the gastrointestinal tract. Most importantly the formulation of oils or gummies must be designed so that the cannabinoid is optimized in its transmucosal permeation. 


CBD topical application is considered the latest breakthrough in managing joint pain and inflammation. Together with its highly effective pain relieving properties, it possesses systemic absorption as well. CBD is absorbed through the skin where it binds to the body’s own CB2 receptors. Once it connects with these receptors, CBD has a pain relieving an anti- inflammatory effect on the body at the site of application.

Topical CBD was also found effective in alleviating the symptoms of the following conditions: seizures, spasticity, weakness, pain, anxiety, insomnia, trigeminal neuralgia, autism, ADD, peripheral neuropathy and fibromyalgia.

The best proven site for application is at the BACK OF THE NECK. This area is rich with Hundreds of thousands of free nerve endings below the skin surface. No other location has such a magnitude of afferent neural input accessible through skin nerve endings. This source of application of CBD is beneficial in treating symptoms of a number of pain-related conditions. Topical CBD therapy is overall well tolerated and provides effective relief. 

Dosing frequency of topical application range from once daily to three times daily depending on severity of condition. The duration of treatment with topical CBD range from several days to as needed. For chronic conditions such as neuropathy continued daily application therapy may be more necessary.

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Overview how CBD oil can help with pain, anxiety and sleep issues

Sleeping CBD Oil

The endocannabinoid signalling system was discovered because receptors in this system [ CB1 and CB2 ] are the targets of compounds In CBD oil.  It has been determined that cannabidiol has high affinity for these receptors.  Endocannabinoids are implicated in numerous physiological and pathological processes such as neuromodulation and inflammation. The current development of endocannabinoid signalling and how this complex system could be pharmacologically manipulated is at the forefront.  

Let’s talk about the Endocannabinoid System (ECS) and how the  CB1 and CB2 receptors play a role in signaling.   This system consists of the endogenous lipid ligands  (anandamide; AEA) and (2-AG) which activate the CB1 and CB2 receptors. The (ECS) regulates functions throughout human body; including neurological , cardiovascular, autonomic, metabolic, and inflammatory states.   The complex cellular interactions modulated by the ECS suggest  prevention of many disease states by changing central nervous and immune cell endocannabinoid signaling.

The following is an in-depth description of how CBD plays a role in the anti-inflammatory process in the body.  Both CB2 receptor agonists and antagonists have been reported to induce anti-inflammatory immune cell responses. And peripheral immune CB2 receptor  activation is anti-inflammatory. PEA has been investigated for its involvement in the control of both excitatory and inhibitory transmission in the murine striatum, a brain region strongly modulated by the ECS.   By  electrophysiologically recording the transmission within neuronal synapses,  it shows that PEA modulates inhibitory synaptic transmission through activation of GPR55 receptor.  GPR55 receptor, an orphan G-protein-coupled receptor, which is involved in processes of inflammation, might be a third cannabinoid receptor.  Furthermore, PEA, acting on GPR55, enhances GABA (gamma-aminobutyric acid)  transmission in the striatum, and triggers a parallel synthesis of 2-AG (2-arachidonyl glycerol) at the postsynaptic site.  This in turn acts  to inhibit GABA release through stimulation of CB1 receptors at pre-synaptic sites. Because CB2 activation dampens inflammatory responses, it has the potential to serve as a molecular target for diminishing  inflammation linked to pathogenic disorders such as MS, ischemic/perfusion injury following an induced stroke, rheumatoid arthritis, inflammatory bowel disease and osteoporosis pain. 

Electrophysiological and neurochemical studies have provided  evidence that endocannabinoids suppress nociceptive (pain) transmission, especially peripherally and at the level of the striatum of the spinal cord.

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What are terpenes and how do they fit in?

True Natural Oils offers high-quality CBD terpenes oil. These products are a blend of CBD and terpenes extracted from the industrial hemp plant. Terpenes are the aromatic and flavorful component of plant essential oils. A well-known terpene is a limonene. … These flavored CBD terps come in many varieties.

It is important to know that cannabinoids and terpenes work together to boost and modulate the effects of one another in the body’s endocannabinoid system (ECS).

A few common terpenes and their effects:


The most common terpene. It is also known as the terpene for its highly-sedative effects.


Common in citrus, it is highly-energetic and a known anti-depressant.


A smokey or woody aroma that is slightly sedative, antioxidant, anti-cancer and antibacterial.


Gastroprotective and a strong anti-inflammatory with a woody, peppery taste.


Energetic and therapeutic, this terpene is common in pine needles, of course.


Floral and citrus, it is used sedation, anti-anxiety relief and anti-depression.

Terpenes are important to note because they help you choose the right CBD product for you. 

Of course there exists many products that only contain CBD Isolate (a refined powder or crystalline solid) which contain no other beneficial cannabinoids, terpenes, or plant extracts, but Ideally you would find products whose therapeutic terpene profiles match your specific ailment.

Our Golden Bee Hemp Pain Salve has a select organic terpene profile, developed by our Product & Research Development Specialist, that specifically targets body pain in addition to its other herbal extracts.

Furthermore, our Ingestible oils are characterized by names such as “Wellness (750 mg)”, “Bliss(1500 mg), “Fusion(3000 mg)”, and “PM(2000 mg)”, each developed with specific terpene profiles for the intended result.

Our Golden Bee Hemp & True Natural Oils products all contain the plant’s natural spectrum of cannabinoids, phytonutrients, terpenes and chlorophyll – a whole plant profile that gives the products powerful anti-inflammatory, antioxidant and antibacterial properties.

Shop Our Lab-Tested, Pharmacist- Formulated Full Spectrum Oils Now!

  • CBD Oils
  • Pet Products
  • Pain Salves
  • Lotion
  • Wound Care
  • Sleep Tinctures

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Defining cannabidiol, CBD and THC

Cannabidiol (CBD) is a naturally occurring compound found in the resinous flower of cannabis, a plant with a rich history as a medicine going back thousands of years. A safe, non-addictive substance, CBD is one of more than a hundred “phytocannabinoids,” which are unique to cannabis and endow the plant with its robust therapeutic profile.

CBD is closely related to another important medicinally active phytocannabinoid: tetrahydrocannabinol (THC), the compound that causes the high that cannabis is famous for. These are the two components of cannabis that have been most studied by scientists.  Other isolated compounds from the cannabis plant include cannabichromene (CBC), cannabigerol (CBG), cannabidivarin (CBDV), among other compounds. While THC has psychoactive effects, CBD, CBC, CBG, and CBDV do not. Many researchers have confirmed the medicinal value of cannabinoids. Cannabinoids have been investigated for possible treatment of seizures, nausea, vomiting, lack of appetite, pain, arthritis, inflammation, and other conditions.

Both CBD and THC have significant therapeutic attributes. But unlike THC, CBD does not make a person feel “stoned” or intoxicated. That’s because CBD and THC act in different ways on different receptors in the brain and body.

CBD can actually lessen or neutralize the psychoactive effects of THC, depending on how much of each compound is consumed. Many people want the health benefits of cannabis without the high – or with less of a high.

The fact that CBD is therapeutically potent as well as non-intoxicating, and easy to take as a CBD oil, makes it an appealing treatment option for those who are cautious about trying cannabis for the first time.

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What to look for in CBD products

When it comes to CBD products, quality is everything. In this rapidly growing industry there are many companies basically selling lessor quality oil slapped with a label claiming to be “high-quality CBD.” In an industry saturated with imposters, it’s important to find companies you can trust and who actually sell a product that works. True Natural Oils is one of these companies. With a mission to provide high-quality CBD oil using state-of-the art innovative extraction techniques, the founders of True Natural Oils have demanded the highest level of care for their products from day one.

With the immense pride True Natural Oils has for using the highest quality hemp in their products, it should come as no surprise that they give the same attention to the extraction process itself. Using the most advanced extraction equipment and technology, each batch of True Natural CBD oil is CO2 extracted at low temperatures. These low temperatures ensure that the extraction process is safe and gentle, preserving all the beneficial cannabinoids, terpenes, and flavonoids that are naturally present in high-quality CBD oil.

Full-spectrum extraction methods mean that you, the consumer, are presented with a CBD oil that stands up to its name. Full-spectrum CBD oils are known to contain other cannabinoids, terpenes, essential oils, and amino acids that work in harmony to create beneficial effects. This is known as the entourage effect.

Each batch is carefully monitored and tested throughout the entire extraction process, then sent to a third-party lab for further testing. True Natural Oils takes pride not only in the quality of their product, but in being completely transparent and open to anyone who wants to look at their current third-party test results posted on their website.

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Education: what is the difference between whole plant extract, full spectrum and CBD Isolate?

The whole plant refers to the entire bud with some leaves and possibly some stems. It does not imply the whole cannabis plant from the roots to the flower. The buds are what is used to obtain extracts that are being compared to the isolated, pure CBD or THC cannabinoids.

According to a study, whole plant, CBD-rich cannabis is superior and more effective than synthetic CBD for the treatment of a number of conditions, including inflammations and pain reduction. When studied, pure CBD extracts showed a dome-shaped effect. This means that at a certain point the effectiveness of CBD extracts reaches a diminishing rate of returns, and taking any more won’t be helpful.

On the other hand, the effectiveness of whole plant cannabis rises with increased usage, continuing beyond the levels reached by CBD extracts. The anti-pain response also increases with increase in dosage.

Fullspectrum CBD is full of all the terpenes, cannabinoids, flavonoids, and fatty acids found in hemp, all of which have therapeutic value of their own and help create what’s know as the entourage effect. Broadspectrum CBD is a little bit of both. Broadspectrum CBD is fullspectrum CBD without any THC.

Full spectrum CBD quite simply means the product contains many cannabinoids beyond CBD, along with other elements of the cannabis or hemp plant, including naturally-occurring terpenes, essential vitamins, fatty acids, protein, and more.

One caveat of full spectrum CBD is it contains a small amount of THC; less than 0.3% THC. 

It’s worth emphasizing that CBD itself is entirely non-psychoactive. While full spectrum oil contains small amounts of THC, it does not contain enough THC to produce any psychoactive effects.


The alternative to full spectrum is CBD isolate which contains only CBD – the CBD molecule is chemically isolated from everything else in the plant.CBD isolate is cannabidiol in its purest form. To produce this extract, CBD is isolated and then refined to strip out any additional cannabinoids, terpenes, and plant components found in the hemp plant. The final product is a fine white powder that contains around 99% cannabidiol.

 CBD isolates have no identifiable amount of THC, the well-known chemical found in cannabis that creates that euphoric high, and they’re stripped of the other beneficial and nutritional compounds like terpenes, flavonoids, vitamins, and protein mentioned above.

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Robin’s Write up: Our Product & Research Development Specialist on how she got started with Natural Oils, Inc.

Hello fellow wellness friends and welcome!

Let me first introduce myself.  I’m Robin McDonald, RPH, and have been asked to be a medical research advocate for True Oils, Inc.  My passion has been inspired a number of ways. But, personally, to have experience of the benefits of True Natural Oils is an absolute miracle.

Allow me to take you back almost two and half years ago. A lady (I considered her a good friend) who came to my pharmacy to fill her prescriptions began telling me about reducing her dosage of her seizure medication.  As any medical professional would do, I discouraged her from doing so. What if she had a recurrence of her seizure? What if she placed herself into danger?  But then she began describing how she started to take these drops of this new oil.  It’s was called CBD oil.   Pulling me over to the side of the pharmacy, she was whispering to me just how she was taking this new mysterious supplement.  I was instantly intrigued! She divulged to me that she had not had a seizure in over 6 months.  And this was with the reduction of her seizure medication.  How could this be?

My friend asked me to contact her personally when I was free to talk about it. So I did and she told me more about how she started to take this oil.  Her neighbor was distributing a CBD oil   product and knew

that she suffered from seizures.  Her neighbor gave her  some  CBD oil to try and within a couple weeks my friend felt the difference.   Not only was she no longer experiencing seizures, but she felt an overall sense of wellness.  No more were her joints aching or stiff. And no more was her thinking or thoughts cloudy.  She became more cognitively aware and clear.  All because she was placing 10 drops of the highest potency product in her morning coffee.  Or sometimes, just under her tongue.

 Now please let me share with you that my same friend has over 5 angioma, blood-filled, tumors on her brain.  This is the culprit for her seizures. Every time she experiences a change of cranial blood pressure, it results in a seizure. With the use of this miraculous CBD oil she is now seizure free.  And continues to be seizure free to this date.

You see, my wellness friends, it is experiences and stories such as these that I am delighted to share with you!  Please look forward for my next blog.  And as always, please reach out with any questions that I may answer for you.  I look forward to helping you onto a better pathway of Health!