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Overview how CBD oil can help with pain, anxiety and sleep issues

Sleeping CBD Oil

The endocannabinoid signalling system was discovered because receptors in this system [ CB1 and CB2 ] are the targets of compounds In CBD oil.  It has been determined that cannabidiol has high affinity for these receptors.  Endocannabinoids are implicated in numerous physiological and pathological processes such as neuromodulation and inflammation. The current development of endocannabinoid signalling and how this complex system could be pharmacologically manipulated is at the forefront.  

Let’s talk about the Endocannabinoid System (ECS) and how the  CB1 and CB2 receptors play a role in signaling.   This system consists of the endogenous lipid ligands  (anandamide; AEA) and (2-AG) which activate the CB1 and CB2 receptors. The (ECS) regulates functions throughout human body; including neurological , cardiovascular, autonomic, metabolic, and inflammatory states.   The complex cellular interactions modulated by the ECS suggest  prevention of many disease states by changing central nervous and immune cell endocannabinoid signaling.

The following is an in-depth description of how CBD plays a role in the anti-inflammatory process in the body.  Both CB2 receptor agonists and antagonists have been reported to induce anti-inflammatory immune cell responses. And peripheral immune CB2 receptor  activation is anti-inflammatory. PEA has been investigated for its involvement in the control of both excitatory and inhibitory transmission in the murine striatum, a brain region strongly modulated by the ECS.   By  electrophysiologically recording the transmission within neuronal synapses,  it shows that PEA modulates inhibitory synaptic transmission through activation of GPR55 receptor.  GPR55 receptor, an orphan G-protein-coupled receptor, which is involved in processes of inflammation, might be a third cannabinoid receptor.  Furthermore, PEA, acting on GPR55, enhances GABA (gamma-aminobutyric acid)  transmission in the striatum, and triggers a parallel synthesis of 2-AG (2-arachidonyl glycerol) at the postsynaptic site.  This in turn acts  to inhibit GABA release through stimulation of CB1 receptors at pre-synaptic sites. Because CB2 activation dampens inflammatory responses, it has the potential to serve as a molecular target for diminishing  inflammation linked to pathogenic disorders such as MS, ischemic/perfusion injury following an induced stroke, rheumatoid arthritis, inflammatory bowel disease and osteoporosis pain. 

Electrophysiological and neurochemical studies have provided  evidence that endocannabinoids suppress nociceptive (pain) transmission, especially peripherally and at the level of the striatum of the spinal cord.

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What are terpenes and how do they fit in?

True Natural Oils offers high-quality CBD terpenes oil. These products are a blend of CBD and terpenes extracted from the industrial hemp plant. Terpenes are the aromatic and flavorful component of plant essential oils. A well-known terpene is a limonene. … These flavored CBD terps come in many varieties.

It is important to know that cannabinoids and terpenes work together to boost and modulate the effects of one another in the body’s endocannabinoid system (ECS).

A few common terpenes and their effects:


The most common terpene. It is also known as the terpene for its highly-sedative effects.


Common in citrus, it is highly-energetic and a known anti-depressant.


A smokey or woody aroma that is slightly sedative, antioxidant, anti-cancer and antibacterial.


Gastroprotective and a strong anti-inflammatory with a woody, peppery taste.


Energetic and therapeutic, this terpene is common in pine needles, of course.


Floral and citrus, it is used sedation, anti-anxiety relief and anti-depression.

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Defining cannabidiol, CBD and THC

Cannabidiol (CBD) is a naturally occurring compound found in the resinous flower of cannabis, a plant with a rich history as a medicine going back thousands of years. A safe, non-addictive substance, CBD is one of more than a hundred “phytocannabinoids,” which are unique to cannabis and endow the plant with its robust therapeutic profile.

CBD is closely related to another important medicinally active phytocannabinoid: tetrahydrocannabinol (THC), the compound that causes the high that cannabis is famous for. These are the two components of cannabis that have been most studied by scientists.  Other isolated compounds from the cannabis plant include cannabichromene (CBC), cannabigerol (CBG), cannabidivarin (CBDV), among other compounds. While THC has psychoactive effects, CBD, CBC, CBG, and CBDV do not. Many researchers have confirmed the medicinal value of cannabinoids. Cannabinoids have been investigated for possible treatment of seizures, nausea, vomiting, lack of appetite, pain, arthritis, inflammation, and other conditions.

Both CBD and THC have significant therapeutic attributes. But unlike THC, CBD does not make a person feel “stoned” or intoxicated. That’s because CBD and THC act in different ways on different receptors in the brain and body.

CBD can actually lessen or neutralize the psychoactive effects of THC, depending on how much of each compound is consumed. Many people want the health benefits of cannabis without the high – or with less of a high.

The fact that CBD is therapeutically potent as well as non-intoxicating, and easy to take as a CBD oil, makes it an appealing treatment option for those who are cautious about trying cannabis for the first time.

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What to look for in CBD products

When it comes to CBD products, quality is everything. In this rapidly growing industry there are many companies basically selling lessor quality oil slapped with a label claiming to be “high-quality CBD.” In an industry saturated with imposters, it’s important to find companies you can trust and who actually sell a product that works. True Natural Oils is one of these companies. With a mission to provide high-quality CBD oil using state-of-the art innovative extraction techniques, the founders of True Natural Oils have demanded the highest level of care for their products from day one.

With the immense pride True Natural Oils has for using the highest quality hemp in their products, it should come as no surprise that they give the same attention to the extraction process itself. Using the most advanced extraction equipment and technology, each batch of True Natural CBD oil is CO2 extracted at low temperatures. These low temperatures ensure that the extraction process is safe and gentle, preserving all the beneficial cannabinoids, terpenes, and flavonoids that are naturally present in high-quality CBD oil.

Full-spectrum extraction methods mean that you, the consumer, are presented with a CBD oil that stands up to its name. Full-spectrum CBD oils are known to contain other cannabinoids, terpenes, essential oils, and amino acids that work in harmony to create beneficial effects. This is known as the entourage effect.

Each batch is carefully monitored and tested throughout the entire extraction process, then sent to a third-party lab for further testing. True Natural Oils takes pride not only in the quality of their product, but in being completely transparent and open to anyone who wants to look at their current third-party test results posted on their website.

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Education: what is the difference between whole plant extract, full spectrum and CBD Isolate?

The whole plant refers to the entire bud with some leaves and possibly some stems. It does not imply the whole cannabis plant from the roots to the flower. The buds are what is used to obtain extracts that are being compared to the isolated, pure CBD or THC cannabinoids.

According to a study, whole plant, CBD-rich cannabis is superior and more effective than synthetic CBD for the treatment of a number of conditions, including inflammations and pain reduction. When studied, pure CBD extracts showed a dome-shaped effect. This means that at a certain point the effectiveness of CBD extracts reaches a diminishing rate of returns, and taking any more won’t be helpful.

On the other hand, the effectiveness of whole plant cannabis rises with increased usage, continuing beyond the levels reached by CBD extracts. The anti-pain response also increases with increase in dosage.

Fullspectrum CBD is full of all the terpenes, cannabinoids, flavonoids, and fatty acids found in hemp, all of which have therapeutic value of their own and help create what’s know as the entourage effect. Broadspectrum CBD is a little bit of both. Broadspectrum CBD is fullspectrum CBD without any THC.

Full spectrum CBD quite simply means the product contains many cannabinoids beyond CBD, along with other elements of the cannabis or hemp plant, including naturally-occurring terpenes, essential vitamins, fatty acids, protein, and more.

One caveat of full spectrum CBD is it contains a small amount of THC; less than 0.3% THC. 

It’s worth emphasizing that CBD itself is entirely non-psychoactive. While full spectrum oil contains small amounts of THC, it does not contain enough THC to produce any psychoactive effects.


The alternative to full spectrum is CBD isolate which contains only CBD – the CBD molecule is chemically isolated from everything else in the plant.CBD isolate is cannabidiol in its purest form. To produce this extract, CBD is isolated and then refined to strip out any additional cannabinoids, terpenes, and plant components found in the hemp plant. The final product is a fine white powder that contains around 99% cannabidiol.

 CBD isolates have no identifiable amount of THC, the well-known chemical found in cannabis that creates that euphoric high, and they’re stripped of the other beneficial and nutritional compounds like terpenes, flavonoids, vitamins, and protein mentioned above.